| In vitro to in vivo extrapolation for high throughput prioritization and decision making SM Bell, X Chang, JF Wambaugh, DG Allen, M Bartels, KLR Brouwer, ... Toxicology in vitro 47, 213-227, 2018 | 203 | 2018 |
| Regulatory assessment and risk management of chemical mixtures: challenges and ways forward SK Bopp, A Kienzler, AN Richarz, SC van der Linden, A Paini, N Parissis, ... Critical Reviews in Toxicology 49 (2), 174-189, 2019 | 174 | 2019 |
| How adverse outcome pathways can aid the development and use of computational prediction models for regulatory toxicology C Wittwehr, H Aladjov, G Ankley, HJ Byrne, J de Knecht, E Heinzle, ... Toxicological Sciences 155 (2), 326-336, 2017 | 164 | 2017 |
| A Review of In Silico Tools as Alternatives to Animal Testing: Principles, Resources and Applications JC Madden, SJ Enoch, A Paini, MTD Cronin Alternatives to Laboratory Animals 48 (4), 146-172, 2020 | 152 | 2020 |
| Putative adverse outcome pathways relevant to neurotoxicity A Bal-Price, KM Crofton, M Sachana, TJ Shafer, M Behl, A Forsby, ... Critical reviews in toxicology 45 (1), 83-91, 2015 | 133 | 2015 |
| Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making A Paini, JA Leonard, E Joossens, JGM Bessems, A Desalegn, JL Dorne, ... Computational Toxicology 9, 61-72, 2019 | 120 | 2019 |
| An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition A Terron, A Bal-Price, A Paini, F Monnet-Tschudi, SH Bennekou, ... Archives of Toxicology 92, 41-82, 2018 | 91 | 2018 |
| Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats A Punt, A Paini, MG Boersma, AP Freidig, T Delatour, G Scholz, B Schilter, ... Toxicological sciences 110 (2), 255-269, 2009 | 86 | 2009 |
| Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods E Berggren, A White, G Ouedraogo, A Paini, AN Richarz, FY Bois, T Exner, ... Computational Toxicology 4, 31-44, 2017 | 85 | 2017 |
| Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity AJ Clippinger, D Allen, H Behrsing, KA BéruBé, MB Bolger, W Casey, ... Toxicology in vitro 52, 131-145, 2018 | 80 | 2018 |
| Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies F Pistollato, F Madia, R Corvi, S Munn, E Grignard, A Paini, A Worth, ... Archives of toxicology 95, 1867-1897, 2021 | 79 | 2021 |
| Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models S Proença, BI Escher, FC Fischer, C Fisher, S Grégoire, NJ Hewitt, B Nicol, ... Toxicology in Vitro 73, 105133, 2021 | 73 | 2021 |
| Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect W Alhusainy, A Paini, A Punt, J Louisse, A Spenkelink, J Vervoort, ... Toxicology and Applied Pharmacology 245 (2), 179-190, 2010 | 73 | 2010 |
| Representing the process of inflammation as key events in adverse outcome pathways DL Villeneuve, B Landesmann, P Allavena, N Ashley, A Bal-Price, ... Toxicological sciences 163 (2), 346-352, 2018 | 69 | 2018 |
| Alternative methods for regulatory toxicology–a state-of-the-art review A Worth, J Barroso, S Bremer, J Burton, S Casati, S Coecke, R Corvi, ... JRC Sci Policy Rep EUR 26797, 1-475, 2014 | 66 | 2014 |
| A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes A Paini, A Punt, F Viton, G Scholz, T Delatour, M Marin-Kuan, B Schilter, ... Toxicology and applied pharmacology 245 (1), 57-66, 2010 | 66 | 2010 |
| New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment A Punt, H Bouwmeester, BJ Blaauboer, S Coecke, B Hakkert, ... Altex 37 (4), 607-622, 2020 | 61 | 2020 |
| In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine M Gajewska, A Paini, JVS Benito, J Burton, A Worth, C Urani, H Briesen, ... Food and Chemical Toxicology 75, 39-49, 2015 | 55 | 2015 |
| Towards a systematic use of effect biomarkers in population and occupational biomonitoring MZ Jeddi, NB Hopf, S Viegas, AB Price, A Paini, C van Thriel, E Benfenati, ... Environment International 146, 106257, 2021 | 53 | 2021 |
| Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications A Paini, JA Leonard, T Kliment, YM Tan, A Worth Regulatory Toxicology and Pharmacology 90, 104-115, 2017 | 50 | 2017 |
