Hee-Woong Lim
Hee-Woong Lim
Assistant Professor, Division of Biomedical Informatics, Cincinnati Children's Hospital
Verified email at - Homepage
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Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
JV Lee, A Carrer, S Shah, NW Snyder, S Wei, S Venneti, AJ Worth, ...
Cell Metabolism 20 (2), 306-319, 2014
EBF2 determines and maintains brown adipocyte identity
S Rajakumari, J Wu, J Ishibashi, HW Lim, AH Giang, KJ Won, RR Reed, ...
Cell Metabolism 17 (4), 562-574, 2013
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
MJ Harms, J Ishibashi, W Wang, HW Lim, S Goyama, T Sato, M Kurokawa, ...
Cell Metabolism 19 (4), 593-604, 2014
Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
DA Hill, HW Lim, YH Kim, WY Ho, YH Foong, VL Nelson, HCB Nguyen, ...
Proceedings of the National Academy of Sciences 115 (22), E5096-E5105, 2018
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells
R Xie, LJ Everett, HW Lim, NA Patel, J Schug, E Kroon, OG Kelly, A Wang, ...
Cell Stem Cell 12 (2), 224-237, 2013
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor
Z Sun, D Feng, B Fang, SE Mullican, SH You, HW Lim, LJ Everett, ...
Molecular Cell 52 (6), 769-782, 2013
Ebf2 is a selective marker of brown and beige adipogenic precursor cells
W Wang, M Kissig, S Rajakumari, L Huang, H Lim, KJ Won, P Seale
Proceedings of the National Academy of Sciences 111 (40), 14466-14471, 2014
Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo
SH You, HW Lim, Z Sun, M Broache, KJ Won, MA Lazar
Nature Structural & Molecular Biology 20 (2), 182-187, 2013
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo
HW Lim, NH Uhlenhaut, A Rauch, J Weiner, S Hübner, N Hübner, KJ Won, ...
Genome Research 25 (6), 836-844, 2015
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
MJ Emmett, HW Lim, J Jager, HJ Richter, M Adlanmerini, LC Peed, ...
Nature 546 (7659), 544-548, 2017
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program
MJ Harms, HW Lim, Y Ho, SN Shapira, J Ishibashi, S Rajakumari, ...
Genes & Development 29 (3), 298-307, 2015
Genetic variation determines PPARγ function and anti-diabetic drug response in vivo
Cell 162 (1), 33–44, 2015
A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
W Wang, J Ishibashi, S Trefely, M Shao, AJ Cowan, A Sakers, HW Lim, ...
Cell Metabolism, 2019
Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers
SE Step, HW Lim, JM Marinis, A Prokesch, DJ Steger, SH You, KJ Won, ...
Genes & Development 28 (9), 1018-1028, 2014
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
RR Stine, SN Shapira, HW Lim, J Ishibashi, M Harms, KJ Won, P Seale
Molecular Metabolism 5 (1), 57-65, 2016
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.
S Shah, WJ Carriveau, J Li, SL Campbell, PK Kopinski, HW Lim, N Daurio, ...
Oncotarget 7 (28), 43713-43730, 2016
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells
BN Ediger, HW Lim, C Juliana, DN Groff, LQT Williams, G Dominguez, ...
Journal of Clinical Investigation 127 (1), 215-229, 2017
EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex
SN Shapira, HW Lim, S Rajakumari, AP Sakers, J Ishibashi, MJ Harms, ...
Genes & development 31 (7), 660-673, 2017
PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing
M Kissig, J Ishibashi, MJ Harms, HW Lim, RR Stine, KJ Won, P Seale
The EMBO journal 36 (11), 1528-1542, 2017
PRDM16 maintains homeostasis of the intestinal epithelium by controlling region-specific metabolism
RR Stine, AP Sakers, T TeSlaa, M Kissig, ZE Stine, CW Kwon, L Cheng, ...
Cell stem cell 25 (6), 830-845. e8, 2019
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