| Structure-based design of a new bisintercalating anthracycline antibiotic JB Chaires, F Leng, T Przewloka, I Fokt, YH Ling, R Perez-Soler, ... Journal of medicinal chemistry 40 (3), 261-266, 1997 | 190 | 1997 |
| Ultratight DNA binding of a new bisintercalating anthracycline antibiotic F Leng, W Priebe, JB Chaires Biochemistry 37 (7), 1743-1753, 1998 | 145 | 1998 |
| Energetics of echinomycin binding to DNA F Leng, JB Chaires, MJ Waring Nucleic Acids Research 31 (21), 6191-6197, 2003 | 112 | 2003 |
| Structure of a DNA−Bisdaunomycin Complex, GG Hu, X Shui, F Leng, W Priebe, JB Chaires, LD Williams Biochemistry 36 (20), 5940-5946, 1997 | 84 | 1997 |
| Potent stimulation of transcription-coupled DNA supercoiling by sequence-specific DNA-binding proteins F Leng, R McMacken Proceedings of the National Academy of Sciences 99 (14), 9139-9144, 2002 | 81 | 2002 |
| Base specific and regioselective chemical cross-linking of daunorubicin to DNA F Leng, R Savkur, I Fokt, T Przewloka, W Priebe, JB Chaires Journal of the American Chemical Society 118 (20), 4731-4738, 1996 | 76 | 1996 |
| Isomerization kinetics of AT hook decapeptide solution structures ER Schenk, ME Ridgeway, MA Park, F Leng, F Fernandez-Lima Analytical chemistry 86 (2), 1210-1214, 2014 | 72 | 2014 |
| Dividing a supercoiled DNA molecule into two independent topological domains F Leng, B Chen, DD Dunlap Proceedings of the National Academy of Sciences 108 (50), 19973-19978, 2011 | 67 | 2011 |
| RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals M Ahmad, Y Xue, SK Lee, JL Martindale, W Shen, W Li, S Zou, ... Nucleic acids research 44 (13), 6335-6349, 2016 | 65 | 2016 |
| Specific recognition of AT-rich DNA sequences by the mammalian high mobility group protein AT-hook 2: a SELEX study T Cui, F Leng Biochemistry 46 (45), 13059-13066, 2007 | 65 | 2007 |
| DNA supercoiling: a regulatory signal for the λ repressor Y Ding, C Manzo, G Fulcrand, F Leng, D Dunlap, L Finzi Proceedings of the National Academy of Sciences 111 (43), 15402-15407, 2014 | 51 | 2014 |
| HMGN1 modulates nucleosome occupancy and DNase I hypersensitivity at the CpG island promoters of embryonic stem cells T Deng, ZI Zhu, S Zhang, F Leng, S Cherukuri, L Hansen, ... Molecular and cellular biology 33 (16), 3377-3389, 2013 | 47 | 2013 |
| Inhibition of high-mobility-group A2 protein binding to DNA by netropsin: a biosensor-surface plasmon resonance assay Y Miao, T Cui, F Leng, WD Wilson Analytical biochemistry 374 (1), 7-15, 2008 | 47 | 2008 |
| DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli G Fulcrand, S Dages, X Zhi, P Chapagain, BS Gerstman, D Dunlap, ... Scientific reports 6 (1), 19243, 2016 | 46 | 2016 |
| Coupling DNA supercoiling to transcription in defined protein systems F Leng, L Amado, R McMacken Journal of Biological Chemistry 279 (46), 47564-47571, 2004 | 46 | 2004 |
| Transcription-coupled hypernegative supercoiling of plasmid DNA by T7 RNA polymerase in Escherichia coli topoisomerase I-deficient strains R Samul, F Leng Journal of molecular biology 374 (4), 925-935, 2007 | 45 | 2007 |
| Energetics of binding the mammalian high mobility group protein HMGA2 to poly (dA-dT) 2 and poly (dA)-poly (dT) T Cui, S Wei, K Brew, F Leng Journal of molecular biology 352 (3), 629-645, 2005 | 45 | 2005 |
| Trapped ion mobility spectrometry of native macromolecular assemblies K Jeanne Dit Fouque, A Garabedian, F Leng, YC Tse-Dinh, ME Ridgeway, ... Analytical chemistry 93 (5), 2933-2941, 2021 | 38 | 2021 |
| A rapid and sensitive high-throughput screening method to identify compounds targeting protein–nucleic acids interactions N Alonso, R Guillen, JW Chambers, F Leng Nucleic acids research 43 (8), e52-e52, 2015 | 35 | 2015 |
| Selective inhibition of bacterial topoisomerase I by alkynyl-bisbenzimidazoles N Ranjan, G Fulcrand, A King, J Brown, X Jiang, F Leng, DP Arya MedChemComm 5 (6), 816-825, 2014 | 31 | 2014 |
