| A TALEN genome-editing system for generating human stem cell-based disease models Q Ding, YK Lee, EAK Schaefer, DT Peters, A Veres, K Kim, ... Cell stem cell 12 (2), 238-251, 2013 | 704 | 2013 |
| Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9 PK Mandal, LMR Ferreira, R Collins, TB Meissner, CL Boutwell, M Friesen, ... Cell stem cell 15 (5), 643-652, 2014 | 595 | 2014 |
| Induced pluripotent stem cell differentiation enables functional validation of GWAS variants in metabolic disease CR Warren, JF O’Sullivan, M Friesen, CE Becker, X Zhang, P Liu, ... Cell stem cell 20 (4), 547-557. e7, 2017 | 159 | 2017 |
| Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells DT Peters, CA Henderson, CR Warren, M Friesen, F Xia, CE Becker, ... Development 143 (9), 1475-1481, 2016 | 63 | 2016 |
| Functional screening of candidate causal genes for insulin resistance in human preadipocytes and adipocytes Z Chen, H Yu, X Shi, CR Warren, LA Lotta, M Friesen, TB Meissner, ... Circulation research 126 (3), 330-346, 2020 | 61 | 2020 |
| Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes M Friesen, CR Warren, H Yu, T Toyohara, Q Ding, MHC Florido, C Sayre, ... Stem cell reports, 2020 | 32 | 2020 |
| Patient hiPSCs identify vascular smooth muscle arylacetamide deacetylase as protective against atherosclerosis T Toyohara, F Roudnicky, MHC Florido, T Nakano, H Yu, S Katsuki, M Lee, ... Cell Stem Cell 27 (1), 147-157. e7, 2020 | 27 | 2020 |
| The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance A Dall’Agnese, JM Platt, MM Zheng, M Friesen, G Dall’Agnese, AM Blaise, ... Nature communications 13 (1), 7522, 2022 | 21 | 2022 |
| A coagulation defect arising from heterozygous premature termination of tissue factor S Schulman, E El-Darzi, MHC Florido, M Friesen, G Merrill-Skoloff, ... The Journal of Clinical Investigation 130 (10), 5302-5312, 2020 | 19 | 2020 |
| Adipocyte metabolism and insulin signaling perturbations: insights from genetics M Friesen, CA Cowan Trends in Endocrinology & Metabolism 30 (6), 396-406, 2019 | 18 | 2019 |
| FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism M Friesen, CA Cowan Biochemical and biophysical research communications 495 (1), 254-260, 2018 | 16 | 2018 |
| Activation of IRF1 in human adipocytes leads to phenotypes associated with metabolic disease M Friesen, R Camahort, YK Lee, F Xia, RE Gerszten, EP Rhee, RC Deo, ... Stem Cell Reports 8 (5), 1164-1173, 2017 | 16 | 2017 |
| Adipocyte insulin receptor activity maintains adipose tissue mass and lifespan M Friesen, CS Hudak, CR Warren, F Xia, CA Cowan Biochemical and biophysical research communications 476 (4), 487-492, 2016 | 14 | 2016 |
| LINE1-mediated reverse transcription and genomic integration of SARS-CoV-2 mRNA detected in virus-infected but not in viral mRNA-transfected cells L Zhang, P Bisht, A Flamier, MI Barrasa, M Friesen, A Richards, ... Viruses 15 (3), 629, 2023 | 11 | 2023 |
| Development of a physiological insulin resistance model in human stem cell–derived adipocytes M Friesen, AS Khalil, MI Barrasa, JF Jeppesen, DJ Mooney, R Jaenisch Science Advances 8 (24), 2022 | 10 | 2022 |
| Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities JJMKAS Johan K. E. Spetz, Mary H. C. Florido, Cameron S. Fraser, Xingping ... Science Advances 8 (45), 2022 | 8 | 2022 |
| SARS-CoV-2 infection of human pluripotent stem cell-derived liver organoids reveals potential mechanisms of liver pathology A Richards, M Friesen, A Khalil, MI Barrasa, L Gehrke, R Jaenisch IScience 25 (10), 2022 | 6 | 2022 |
| Modeling the effects of severe metabolic disease by genome editing of hPSC-derived endothelial cells reveals an inflammatory phenotype F Roudnicky, Y Lan, M Friesen, G Dernick, JD Zhang, A Staempfli, ... International Journal of Molecular Sciences 20 (24), 6201, 2019 | 3 | 2019 |
| LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells. Viruses. 2023; 15, 629 L Zhang, P Bisht, A Flamier, MI Barrasa, M Friesen, A Richards, ... | 2 | 2023 |
| SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection A Richards, A Khalil, M Friesen, T Whitfield, T Lungjangwa, L Gehrke, ... bioRxiv, 2023.08. 06.552160, 2023 | | 2023 |
Torsten MeissnerHarvard Medical School, Department of SurgeryVerified email at bidmc.harvard.edu
