Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks Y Shi, P Kirwan, FJ Livesey Nature protocols 7 (10), 1836-1846, 2012 | 947 | 2012 |
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses Y Shi, P Kirwan, J Smith, HPC Robinson, FJ Livesey Nature neuroscience 15 (3), 477-486, 2012 | 911 | 2012 |
A human stem cell model of early Alzheimer’s disease pathology in Down syndrome Y Shi, P Kirwan, J Smith, G MacLean, SH Orkin, FJ Livesey Science translational medicine 4 (124), 124ra29-124ra29, 2012 | 376 | 2012 |
APP metabolism regulates tau proteostasis in human cerebral cortex neurons S Moore, LDB Evans, T Andersson, E Portelius, J Smith, TB Dias, ... Cell reports 11 (5), 689-696, 2015 | 221 | 2015 |
Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro P Kirwan, B Turner-Bridger, M Peter, A Momoh, D Arambepola, ... Development 142 (18), 3178-3187, 2015 | 127 | 2015 |
The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro FR Ali, K Cheng, P Kirwan, S Metcalfe, FJ Livesey, RA Barker, A Philpott Development 141 (11), 2216-2224, 2014 | 105 | 2014 |
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities T Sonoyama, LKJ Stadler, M Zhu, JM Keogh, E Henning, F Hisama, ... Scientific reports 10 (1), 9028, 2020 | 43 | 2020 |
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis P Kirwan, RG Kay, B Brouwers, V Herranz-Pérez, M Jura, P Larraufie, ... Molecular metabolism 17, 82-97, 2018 | 29 | 2018 |
Proopiomelanocortin processing in the hypothalamus is directly regulated by saturated fat: implications for the development of obesity DS Razolli, TM De Araújo, MR Sant'Ana, P Kirwan, DE Cintra, FT Merkle, ... Neuroendocrinology 110 (1-2), 92-104, 2020 | 25 | 2020 |
Generation and characterization of functional human hypothalamic neurons P Kirwan, M Jura, FT Merkle Current protocols in neuroscience 81 (1), 3.33. 1-3.33. 24, 2017 | 23 | 2017 |
Rapid sensing of l-leucine by human and murine hypothalamic neurons: neurochemical and mechanistic insights N Heeley, P Kirwan, T Darwish, M Arnaud, ML Evans, FT Merkle, ... Molecular metabolism 10, 14-27, 2018 | 18 | 2018 |
Human POMC processing in vitro and in vivo revealed by quantitative peptidomics P Kirwan, R Kay, B Brouwers, V Herranz-Perez, M Jura, P Larraufie, ... bioRxiv, 257121, 2018 | | 2018 |
Human Stem Cell Models of Neurodevelopmental Disorders P Kirwan, FJ Livesey The Genetics of Neurodevelopmental Disorders, 239-260, 2015 | | 2015 |
Development and function of human cerebral cortex neuronal networks from pluripotent stem cells M Peter, P Kirwan, R Livesey Proceedings of The Physiological Society, 2015 | | 2015 |
Modelling human cortical networks in development and Down syndrome using pluripotent stem cells P Kirwan University of Cambridge, 2014 | | 2014 |