| Single-cell transcriptomic analysis of Alzheimer’s disease H Mathys, J Davila-Velderrain, Z Peng, F Gao, S Mohammadi, JZ Young, ... Nature 570 (7761), 332-337, 2019 | 1913 | 2019 |
| Rare and low-frequency coding variants alter human adult height E Marouli, M Graff, C Medina-Gomez, KS Lo, AR Wood, TR Kjaer, RS Fine, ... Nature 542 (7640), 186-190, 2017 | 670 | 2017 |
| Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity V Turcot, Y Lu, HM Highland, C Schurmann, AE Justice, RS Fine, ... Nature genetics 50 (1), 26-41, 2018 | 365 | 2018 |
| APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia G Sienski, P Narayan, JM Bonner, N Kory, S Boland, AA Arczewska, ... Science translational medicine 13 (583), eaaz4564, 2021 | 228 | 2021 |
| High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human X Wang, L He, SM Goggin, A Saadat, L Wang, N Sinnott-Armstrong, ... Nature communications 9 (1), 5380, 2018 | 148 | 2018 |
| NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data L He, J Davila-Velderrain, TS Sumida, DA Hafler, M Kellis, AM Kulminski Communications biology 4 (1), 629, 2021 | 82 | 2021 |
| Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample A Loukola, J Wedenoja, K Keskitalo-Vuokko, U Broms, T Korhonen, ... Molecular psychiatry 19 (5), 615-624, 2014 | 79 | 2014 |
| The durations of past sickness absences predict future absence episodes M Laaksonen, L He, J Pitkäniemi Journal of occupational and environmental medicine 55 (1), 87-92, 2013 | 73 | 2013 |
| Discovery of high-confidence human protein-coding genes and exons by whole-genome PhyloCSF helps elucidate 118 GWAS loci JM Mudge, I Jungreis, T Hunt, JM Gonzalez, JC Wright, M Kay, ... Genome research 29 (12), 2073-2087, 2019 | 63 | 2019 |
| Pleiotropic meta-analyses of longitudinal studies discover novel genetic variants associated with age-related diseases L He, Y Kernogitski, I Kulminskaya, Y Loika, KG Arbeev, E Loiko, ... Frontiers in genetics 7, 179, 2016 | 43* | 2016 |
| Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland L Lehtoranta, K Kalima, L He, M Lappalainen, M Roivainen, M Närkiö, ... Journal of Clinical Virology 60 (3), 276-281, 2014 | 43 | 2014 |
| Apolipoprotein E region molecular signatures of Alzheimer's disease AM Kulminski, J Huang, J Wang, L He, Y Loika, I Culminskaya Aging Cell 17 (4), e12779, 2018 | 34 | 2018 |
| Genetic and regulatory architecture of Alzheimer's disease in the APOE region AM Kulminski, L Shu, Y Loika, L He, A Nazarian, K Arbeev, S Ukraintseva, ... Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 12 (1 …, 2020 | 27 | 2020 |
| Pleiotropic associations of allelic variants in a 2q22 region with risks of major human diseases and mortality AM Kulminski, L He, I Culminskaya, Y Loika, Y Kernogitski, KG Arbeev, ... PLoS Genetics 12 (11), e1006314, 2016 | 27 | 2016 |
| Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study L He, I Culminskaya, Y Loika, KG Arbeev, O Bagley, M Duan, AI Yashin, ... Experimental gerontology 107, 74-86, 2018 | 26 | 2018 |
| Impact of classical risk factors of type 2 diabetes among Asian Indian, Chinese and Japanese populations L He, J Tuomilehto, Q Qiao, S Söderberg, M Daimon, J Chambers, ... Diabetes & metabolism 41 (5), 401-409, 2015 | 25 | 2015 |
| Fast algorithms for conducting large-scale GWAS of age-at-onset traits using cox mixed-effects models L He, AM Kulminski Genetics 215 (1), 41-58, 2020 | 24 | 2020 |
| Probiotics and respiratory and gastrointestinal tract infections in Finnish military conscripts–a randomised placebo-controlled double-blinded study K Kalima, L Lehtoranta, L He, J Pitkäniemi, R Lundell, I Julkunen, ... Beneficial microbes 7 (4), 463-471, 2016 | 21 | 2016 |
| Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease L He, Y Loika, Y Park, Genotype Tissue Expression (GTEx) consortium, ... Translational psychiatry 11 (1), 146, 2021 | 19 | 2021 |
| Estimating modifying effect of age on genetic and environmental variance components in twin models L He, MJ Sillanpää, K Silventoinen, J Kaprio, J Pitkäniemi Genetics 202 (4), 1313-1328, 2016 | 18 | 2016 |
Manolis KellisProfessor of Computer Science, MIT and Broad InstituteVerified email at mit.edu
