Klaas Martinus Pos
Klaas Martinus Pos
Professor Membrane Transport Machineries
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Cited by
Cited by
Multidrug efflux pumps: structure, function and regulation
D Du, X Wang-Kan, A Neuberger, HW Van Veen, KM Pos, LJV Piddock, ...
Nature Reviews Microbiology 16 (9), 523-539, 2018
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism
MA Seeger, A Schiefner, T Eicher, F Verrey, K Diederichs, KM Pos
Science 313 (5791), 1295-1298, 2006
Drug transport mechanism of the AcrB efflux pump
KM Pos
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (5), 782-793, 2009
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
T Eicher, H Cha, MA Seeger, L Brandstätter, J El-Delik, JA Bohnert, ...
Proceedings of the National Academy of Sciences 109 (15), 5687-5692, 2012
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations
SMR Camargo, D Singer, V Makrides, K Huggel, KM Pos, CA Wagner, ...
Gastroenterology 136 (3), 872-882. e3, 2009
Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria
M Masi, M Réfregiers, KM Pos
Nature microbiology 2 (3), 1-7, 2017
Tripartite assembly of RND multidrug efflux pumps
L Daury, F Orange, JC Taveau, A Verchère, L Monlezun, C Gounou, ...
Nature communications 7 (1), 10731, 2016
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
H Sjuts, AV Vargiu, SM Kwasny, ST Nguyen, HS Kim, X Ding, AR Ornik, ...
Proceedings of the National Academy of Sciences 113 (13), 3509-3514, 2016
Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
T Eicher, MA Seeger, C Anselmi, W Zhou, L Brandstätter, F Verrey, ...
elife 3, e03145, 2014
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB
MA Seeger, C Von Ballmoos, T Eicher, L Brandstätter, F Verrey, ...
Nature structural & molecular biology 15 (2), 199-205, 2008
Approved drugs containing thiols as inhibitors of metallo-β-lactamases: strategy to combat multidrug-resistant bacteria
FM Klingler, TA Wichelhaus, D Frank, J Cuesta-Bernal, J El-Delik, ...
Journal of medicinal chemistry 58 (8), 3626-3630, 2015
Structure, mechanism and cooperation of bacterial multidrug transporters
D Du, HW van Veen, S Murakami, KM Pos, BF Luisi
Current opinion in structural biology 33, 76-91, 2015
The Escherichia coli Citrate Carrier CitT: a Member of a Novel Eubacterial Transporter Family Related to the 2-Oxoglutarate/Malate Translocator from Spinach …
KM Pos, P Dimroth, M Bott
Journal of Bacteriology 180 (16), 4160-4165, 1998
The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance
MA Seeger, K Diederichs, T Eicher, L Brandstatter, A Schiefner, F Verrey, ...
Current drug targets 9 (9), 729-749, 2008
Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB
JA Bohnert, S Schuster, MA Seeger, E Fähnrich, KM Pos, WV Kern
Journal of bacteriology 190 (24), 8225-8229, 2008
A natural prodrug activation mechanism in nonribosomal peptide synthesis
D Reimer, KM Pos, M Thines, P Grün, HB Bode
Nature chemical biology 7 (12), 888-890, 2011
Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
I Alav, J Kobylka, MS Kuth, KM Pos, M Picard, JMA Blair, VN Bavro
Chemical Reviews 121 (9), 5479-5596, 2021
AcrB: a mean, keen, drug efflux machine
J Kobylka, MS Kuth, RT Müller, ER Geertsma, KM Pos
Annals of the New York Academy of Sciences 1459 (1), 38-68, 2020
Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway
T Ramadan, SMR Camargo, V Summa, P Hunziker, S Chesnov, KM Pos, ...
Journal of cellular physiology 206 (3), 771-779, 2006
Localization of peptidases in lactococci
PST Tan, MP Chapot-Chartier, KM Pos, M Rousseau, CY Boquien, ...
Applied and Environmental Microbiology 58 (1), 285-290, 1992
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