| The coming of age of de novo protein design PS Huang, SE Boyken, D Baker Nature 537 (7620), 320-327, 2016 | 1435 | 2016 |
| A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield R Pejchal, KJ Doores, LM Walker, R Khayat, PS Huang, SK Wang, ... Science 334 (6059), 1097-1103, 2011 | 880 | 2011 |
| Rational HIV immunogen design to target specific germline B cell receptors J Jardine, JP Julien, S Menis, T Ota, O Kalyuzhniy, A McGuire, D Sok, ... Science 340 (6133), 711-716, 2013 | 821 | 2013 |
| Macromolecular modeling and design in Rosetta: recent methods and frameworks JK Leman, BD Weitzner, SM Lewis, J Adolf-Bryfogle, N Alam, RF Alford, ... Nature methods 17 (7), 665-680, 2020 | 653 | 2020 |
| Protein structure determination using metagenome sequence data S Ovchinnikov, H Park, N Varghese, PS Huang, GA Pavlopoulos, DE Kim, ... Science 355 (6322), 294-298, 2017 | 540 | 2017 |
| Design of a hyperstable 60-subunit protein icosahedron Y Hsia, JB Bale, S Gonen, D Shi, W Sheffler, KK Fong, U Nattermann, ... Nature 535 (7610), 136-139, 2016 | 469 | 2016 |
| Accurate de novo design of hyperstable constrained peptides G Bhardwaj, VK Mulligan, CD Bahl, JM Gilmore, PJ Harvey, O Cheneval, ... Nature 538 (7625), 329-335, 2016 | 416 | 2016 |
| RosettaRemodel: a generalized framework for flexible backbone protein design PS Huang, YEA Ban, F Richter, I Andre, R Vernon, WR Schief, D Baker PloS one 6 (8), e24109, 2011 | 411 | 2011 |
| De novo design of a fluorescence-activating β-barrel J Dou, AA Vorobieva, W Sheffler, LA Doyle, H Park, MJ Bick, B Mao, ... Nature 561 (7724), 485-491, 2018 | 352 | 2018 |
| High thermodynamic stability of parametrically designed helical bundles PS Huang, G Oberdorfer, C Xu, XY Pei, BL Nannenga, JM Rogers, ... science 346 (6208), 481-485, 2014 | 326 | 2014 |
| Exploring the repeat protein universe through computational protein design TJ Brunette, F Parmeggiani, PS Huang, G Bhabha, DC Ekiert, ... Nature 528 (7583), 580-584, 2015 | 306 | 2015 |
| De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy PS Huang, K Feldmeier, F Parmeggiani, DA Fernandez Velasco, ... Nature chemical biology 12 (1), 29-34, 2016 | 286 | 2016 |
| Progen: Language modeling for protein generation A Madani, B McCann, N Naik, NS Keskar, N Anand, RR Eguchi, ... arXiv preprint arXiv:2004.03497, 2020 | 263 | 2020 |
| Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold ML Azoitei, BE Correia, YEA Ban, C Carrico, O Kalyuzhniy, L Chen, ... Science 334 (6054), 373-376, 2011 | 246 | 2011 |
| Generative modeling for protein structures N Anand, P Huang Advances in neural information processing systems 31, 2018 | 201 | 2018 |
| Protein sequence design with a learned potential N Anand, R Eguchi, II Mathews, CP Perez, A Derry, RB Altman, PS Huang Nature communications 13 (1), 746, 2022 | 180 | 2022 |
| Computational design of transmembrane pores C Xu, P Lu, TM Gamal El-Din, XY Pei, MC Johnson, A Uyeda, MJ Bick, ... Nature 585 (7823), 129-134, 2020 | 146 | 2020 |
| A de novo designed protein–protein interface PS Huang, JJ Love, SL Mayo Protein Science 16 (12), 2770-2774, 2007 | 129 | 2007 |
| Theoretical basis for stabilizing messenger RNA through secondary structure design HK Wayment-Steele, DS Kim, CA Choe, JJ Nicol, R Wellington-Oguri, ... Nucleic acids research 49 (18), 10604-10617, 2021 | 115 | 2021 |
| Control of repeat-protein curvature by computational protein design K Park, BW Shen, F Parmeggiani, PS Huang, BL Stoddard, D Baker Nature structural & molecular biology 22 (2), 167-174, 2015 | 107 | 2015 |
