David A. Sinclair
David A. Sinclair
Harvard Medical School (Genetics)
Verified email at - Homepage
Cited by
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Resveratrol improves health and survival of mice on a high-calorie diet
JA Baur, KJ Pearson, NL Price, HA Jamieson, C Lerin, A Kalra, ...
Nature 444 (7117), 337-342, 2006
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KJ Bitterman, HY Cohen, DW Lamming, S Lavu, JG Wood, RE Zipkin, ...
Nature 425, 191-196, 2003
Therapeutic potential of resveratrol: the in vivo evidence
JA Baur, DA Sinclair
Nature reviews Drug discovery 5 (6), 493-506, 2006
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
A Brunet, LB Sweeney, JF Sturgill, KF Chua, PL Greer, Y Lin, H Tran, ...
science 303 (5666), 2011-2015, 2004
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
HY Cohen, C Miller, KJ Bitterman, NR Wall, B Hekking, B Kessler, ...
science 305 (5682), 390-392, 2004
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood, B Rogina, S Lavu, K Howitz, SL Helfand, M Tatar, D Sinclair
Nature 430 (7000), 686-689, 2004
Mammalian sirtuins: biological insights and disease relevance
MC Haigis, DA Sinclair
Annual Review of Pathology: Mechanisms of Disease 5, 253-295, 2010
Sirtuins in mammals: insights into their biological function
S Michan, D Sinclair
Biochemical Journal 404 (1), 1-13, 2007
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
JC Milne, PD Lambert, S Schenk, DP Carney, JJ Smith, DJ Gagne, L Jin, ...
Nature 450 (7170), 712-716, 2007
Extrachromosomal rDNA circles—a cause of aging in yeast
DA Sinclair, L Guarente
Cell 91 (7), 1033-1042, 1997
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
NL Price, AP Gomes, AJY Ling, FV Duarte, A Martin-Montalvo, BJ North, ...
Cell metabolism 15 (5), 675-690, 2012
Metformin improves healthspan and lifespan in mice
A Martin-Montalvo, EM Mercken, SJ Mitchell, HH Palacios, PL Mote, ...
Nature communications 4 (1), 2192, 2013
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
AP Gomes, NL Price, AJY Ling, JJ Moslehi, MK Montgomery, L Rajman, ...
Cell 155 (7), 1624-1638, 2013
The intersection between aging and cardiovascular disease
BJ North, DA Sinclair
Circulation research 110 (8), 1097-1108, 2012
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
KJ Pearson, JA Baur, KN Lewis, L Peshkin, NL Price, N Labinskyy, ...
Cell metabolism 8 (2), 157-168, 2008
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
KJ Bitterman, RM Anderson, HY Cohen, M Latorre-Esteves, DA Sinclair
Journal of Biological Chemistry 277 (47), 45099-45107, 2002
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
D Kim, MD Nguyen, MM Dobbin, A Fischer, F Sananbenesi, JT Rodgers, ...
The EMBO journal 26 (13), 3169-3179, 2007
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
H Yang, T Yang, JA Baur, E Perez, T Matsui, JJ Carmona, DW Lamming, ...
Cell 130 (6), 1095-1107, 2007
Why does COVID-19 disproportionately affect older people?
AL Mueller, MS McNamara, DA Sinclair
Aging (albany NY) 12 (10), 9959, 2020
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