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Richard Y-C Huang
Richard Y-C Huang
Director at Johnson & Johnson Innovative Medicine
Verified email at its.jnj.com
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Cited by
Year
VISTA is an acidic pH-selective ligand for PSGL-1
RJ Johnston, LJ Su, J Pinckney, D Critton, E Boyer, A Krishnakumar, ...
Nature 574 (7779), 565-570, 2019
2642019
Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry
RYC Huang, G Chen
Analytical and bioanalytical chemistry 406, 6541-6558, 2014
992014
Fast photochemical oxidation of proteins (FPOP) maps the epitope of EGFR binding to adnectin
Y Yan, G Chen, H Wei, RYC Huang, J Mo, DL Rempel, AA Tymiak, ...
Journal of The American Society for Mass Spectrometry 25 (12), 2084-2092, 2014
972014
Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization
RYC Huang, K Garai, C Frieden, ML Gross
Biochemistry 50 (43), 9273-9282, 2011
972011
Site-Selective functionalization of methionine residues via photoredox catalysis
J Kim, BX Li, RYC Huang, JX Qiao, WR Ewing, DWC MacMillan
Journal of the American Chemical Society 142 (51), 21260-21266, 2020
952020
Psb27, a transiently associated protein, binds to the chlorophyll binding protein CP43 in photosystem II assembly intermediates
H Liu, RYC Huang, J Chen, ML Gross, HB Pakrasi
Proceedings of the National Academy of Sciences 108 (45), 18536-18541, 2011
952011
Radiosynthesis and preclinical PET evaluation of 89Zr-nivolumab (BMS-936558) in healthy non-human primates
EL Cole, J Kim, DJ Donnelly, RA Smith, D Cohen, V Lafont, PE Morin, ...
Bioorganic & Medicinal Chemistry 25 (20), 5407-5414, 2017
892017
Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and …
J Li, H Wei, SR Krystek Jr, D Bond, TM Brender, D Cohen, J Feiner, ...
Analytical Chemistry 89 (4), 2250-2258, 2017
892017
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation
BX Li, DK Kim, S Bloom, RYC Huang, JX Qiao, WR Ewing, DG Oblinsky, ...
Nature chemistry 13 (9), 902-908, 2021
812021
Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry
RYC Huang, JG Laing, EM Kanter, VM Berthoud, M Bao, HW Rohrs, ...
Journal of proteome research 10 (3), 1098-1109, 2011
772011
Mass spectrometry-based carboxyl footprinting of proteins: method evaluation
H Zhang, J Wen, RYC Huang, RE Blankenship, ML Gross
International journal of mass spectrometry 312, 78-86, 2012
652012
Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics
KS Li, G Chen, J Mo, RYC Huang, EG Deyanova, BR Beno, SR O’Neil, ...
Analytical chemistry 89 (14), 7742-7749, 2017
572017
Characterization of antibody–drug conjugates by mass spectrometry: advances and future trends
RYC Huang, G Chen
Drug discovery today 21 (5), 850-855, 2016
552016
Interlaboratory Comparison of Hydrogen–Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb
JW Hudgens, ES Gallagher, I Karageorgos, KW Anderson, JJ Filliben, ...
Analytical chemistry 91 (11), 7336-7345, 2019
522019
Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
C Wang, N Lonberg, AJ Korman, MJ Selby, M Srinivasan, K Henning, ...
US Patent 9,228,016, 2016
522016
Mass spectrometry-based footprinting reveals structural dynamics of loop E of the chlorophyll-binding protein CP43 during photosystem II assembly in the cyanobacterium …
H Liu, J Chen, RYC Huang, D Weisz, ML Gross, HB Pakrasi
Journal of Biological Chemistry 288 (20), 14212-14220, 2013
472013
Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen–Deuterium Exchange, Cross-linking, and Molecular Docking
MM Zhang, RYC Huang, BR Beno, EG Deyanova, J Li, G Chen, ML Gross
Analytical Chemistry 92 (13), 9086-9094, 2020
462020
Effects of desialylation on human α1-Acid Glycoprotein–ligand interactions
RYC Huang, JW Hudgens
Biochemistry 52 (40), 7127-7136, 2013
462013
Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction
RYC Huang, SR Krystek Jr, N Felix, RF Graziano, M Srinivasan, ...
mAbs 10 (1), 95-103, 2018
432018
An Integrated Approach for Determining a Protein–Protein Binding Interface in Solution and an Evaluation of Hydrogen–Deuterium Exchange Kinetics for Adjudicating Candidate …
MM Zhang, BR Beno, RYC Huang, J Adhikari, EG Deyanova, J Li, G Chen, ...
Analytical Chemistry 91 (24), 15709-15717, 2019
422019
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