| Computational drug design accommodating receptor flexibility: the relaxed complex scheme JH Lin, AL Perryman, JR Schames, JA McCammon Journal of the American Chemical Society 124 (20), 5632-5633, 2002 | 506 | 2002 |
| HIV‐1 protease molecular dynamics of a wild‐type and of the V82F/I84V mutant: Possible contributions to drug resistance and a potential new target site for drugs AL Perryman, JH Lin, JA McCammon Protein Science 13 (4), 1108-1123, 2004 | 292 | 2004 |
| The relaxed complex method: Accommodating receptor flexibility for drug design with an improved scoring scheme JH Lin, AL Perryman, JR Schames, JA McCammon Biopolymers: Original Research on Biomolecules 68 (1), 47-62, 2003 | 228 | 2003 |
| Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2 YC Lin, JH Lin, CW Chou, YF Chang, SH Yeh, CC Chen Cancer research 68 (7), 2375-2383, 2008 | 220 | 2008 |
| idTarget: a web server for identifying protein targets of small chemical molecules with robust scoring functions and a divide-and-conquer docking approach JC Wang, PY Chu, CM Chen, JH Lin Nucleic acids research 40 (W1), W393-W399, 2012 | 185 | 2012 |
| Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design RE Amaro, DDL Minh, LS Cheng, WM Lindstrom, AJ Olson, JH Lin, WW Li, ... Journal of the American Chemical Society 129 (25), 7764-7765, 2007 | 183 | 2007 |
| Increased membrane affinity of the C1 domain of protein kinase Cδ compensates for the lack of involvement of its C2 domain in membrane recruitment JR Giorgione, JH Lin, JA McCammon, AC Newton Journal of Biological Chemistry 281 (3), 1660-1669, 2006 | 157 | 2006 |
| Stability of a melittin pore in a lipid bilayer: a molecular dynamics study JH Lin, A Baumgaertner Biophysical Journal 78 (4), 1714-1724, 2000 | 129 | 2000 |
| MEDock: a web server for efficient prediction of ligand binding sites based on a novel optimization algorithm DTH Chang, YJ Oyang, JH Lin Nucleic acids research 33 (suppl_2), W233-W238, 2005 | 120 | 2005 |
| Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study PL Chen, SR Shih, PW Wang, YC Lin, CC Chu, JH Lin, SC Chen, ... Nature communications 6 (1), 7633, 2015 | 108 | 2015 |
| Improvement of porphyrins for G-quadruplex DNA targeting C Romera, O Bombarde, R Bonnet, D Gomez, P Dumy, P Calsou, ... Biochimie 93 (8), 1310-1317, 2011 | 98 | 2011 |
| Bridging implicit and explicit solvent approaches for membrane electrostatics JH Lin, NA Baker, JA McCammon Biophysical Journal 83 (3), 1374-1379, 2002 | 95 | 2002 |
| A new drug design targeting the adenosinergic system for Huntington's disease NK Huang, JH Lin, JT Lin, CI Lin, EM Liu, CJ Lin, WP Chen, YC Shen, ... PloS one 6 (6), e20934, 2011 | 85 | 2011 |
| A new drug design targeting the adenosinergic system for Huntington's disease NK Huang, JH Lin, JT Lin, CI Lin, EM Liu, CJ Lin, WP Chen, YC Shen, ... PloS one 6 (6), e20934, 2011 | 85 | 2011 |
| Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment JB Chen, TR Chern, TT Wei, CC Chen, JH Lin, JM Fang Journal of medicinal chemistry 56 (9), 3645-3655, 2013 | 75 | 2013 |
| Accommodating protein flexibility for structure-based drug design JH Lin Current topics in medicinal chemistry 11 (2), 171-178, 2011 | 75 | 2011 |
| Restrained molecular dynamics simulations of HIV‐1 protease: the first step in validating a new target for drug design AL Perryman, JH Lin, JA McCammon Biopolymers: Original Research on Biomolecules 82 (3), 272-284, 2006 | 67 | 2006 |
| Robust scoring functions for protein–ligand interactions with quantum chemical charge models JC Wang, JH Lin, CM Chen, AL Perryman, AJ Olson Journal of chemical information and modeling 51 (10), 2528-2537, 2011 | 63 | 2011 |
| Scoring functions for prediction of protein-ligand interactions JC Wang, JH Lin Current pharmaceutical design 19 (12), 2174-2182, 2013 | 61 | 2013 |
| Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate SF Chen, NL Huang, JH Lin, CC Wu, YR Wang, YJ Yu, MK Gilson, ... Nature communications 9 (1), 3085, 2018 | 53 | 2018 |
