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zhen cai
wake forest baptist health
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Year
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
CH Chan, JK Morrow, CF Li, Y Gao, G Jin, A Moten, LJ Stagg, JE Ladbury, ...
Cell 154 (3), 556-568, 2013
3972013
Lactate is a natural suppressor of RLR signaling by targeting MAVS
W Zhang, G Wang, ZG Xu, H Tu, F Hu, J Dai, Y Chang, Y Chen, Y Lu, ...
Cell 178 (1), 176-189. e15, 2019
3842019
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
F Han, CF Li, Z Cai, X Zhang, G Jin, WN Zhang, C Xu, CY Wang, J Morrow, ...
Nature communications 9 (1), 4728, 2018
1442018
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, ...
Nature cell biology 21 (2), 214-225, 2019
1372019
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism
Z Cai, JS Zhao, JJ Li, DN Peng, XY Wang, TL Chen, YP Qiu, PP Chen, ...
Molecular & Cellular Proteomics 9 (12), 2617-2628, 2010
1362010
Phosphorylation of PDHA by AMPK drives TCA cycle to promote cancer metastasis
Z Cai, CF Li, F Han, C Liu, A Zhang, CC Hsu, D Peng, X Zhang, G Jin, ...
Molecular cell 80 (2), 263-278. e7, 2020
1342020
Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress
SW Lee, CF Li, G Jin, Z Cai, F Han, CH Chan, WL Yang, BK Li, ...
Molecular cell 57 (6), 1022-1033, 2015
1282015
K63-linked ubiquitination in kinase activation and cancer
G Wang, Y Gao, L Li, G Jin, Z Cai, JI Chao, HK Lin
Frontiers in oncology 2, 5, 2012
1242012
A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis
AH Rezaeian, CF Li, CY Wu, X Zhang, J Delacerda, MJ You, F Han, Z Cai, ...
Nature cell biology 19 (1), 38-51, 2017
1022017
Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells
ZJ Sun, Y Wang, Z Cai, PP Chen, XJ Tong, D Xie
British journal of cancer 99 (10), 1656-1667, 2008
1022008
The Skp2 pathway: a critical target for cancer therapy
Z Cai, A Moten, D Peng, CC Hsu, BS Pan, R Manne, H Li, HK Lin
Seminars in cancer biology 67, 16-33, 2020
992020
Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1
G Jin, SW Lee, X Zhang, Z Cai, Y Gao, PC Chou, AH Rezaeian, F Han, ...
Molecular cell 58 (6), 989-1000, 2015
792015
Cycles of ubiquitination and deubiquitination critically regulate growth factor–mediated activation of Akt signaling
WL Yang, G Jin, CF Li, YS Jeong, A Moten, D Xu, Z Feng, W Chen, Z Cai, ...
Science signaling 6 (257), ra3-ra3, 2013
732013
AMPK signaling and its targeting in cancer progression and treatment
CC Hsu, D Peng, Z Cai, HK Lin
Seminars in cancer biology 85, 52-68, 2022
612022
Cilia loss sensitizes cells to transformation by activating the mevalonate pathway
YZ Deng, Z Cai, S Shi, H Jiang, YR Shang, N Ma, JJ Wang, DX Guan, ...
Journal of Experimental Medicine 215 (1), 177-195, 2018
562018
Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
CC Hsu, X Zhang, G Wang, W Zhang, Z Cai, BS Pan, H Gu, C Xu, G Jin, ...
Molecular cell 81 (18), 3803-3819. e7, 2021
412021
hPCL3s promotes hepatocellular carcinoma metastasis by activating β-catenin signaling
Z Cai, ZY Qian, H Jiang, N Ma, Z Li, LY Liu, XX Ren, YR Shang, JJ Wang, ...
Cancer research 78 (10), 2536-2549, 2018
292018
SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling
C Xu, G Jin, H Wu, W Cui, YH Wang, RK Manne, G Wang, W Zhang, ...
The Journal of Clinical Investigation 132 (5), 2022
252022
Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance
C Liu, Z Cai, G Jin, D Peng, BS Pan, X Zhang, F Han, X Xu, HK Lin
Cell discovery 4 (1), 54, 2018
162018
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance
T Chen, ZG Xu, J Luo, RK Manne, Z Wang, CC Hsu, BS Pan, Z Cai, ...
Cell Metabolism 35 (10), 1782-1798. e8, 2023
102023
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