Estrogen receptor (ER) α mutations in breast cancer: hidden in plain sight SAW Fuqua, G Gu, Y Rechoum Breast cancer research and treatment 144, 11-19, 2014 | 227 | 2014 |
ESR1 mutations in breast cancer D Dustin, G Gu, SAW Fuqua Cancer 125 (21), 3714-3728, 2019 | 207 | 2019 |
Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment G Gu, D Dustin, SAW Fuqua Current opinion in pharmacology 31, 97-103, 2016 | 175 | 2016 |
Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation S Catalano, C Giordano, P Rizza, G Gu, I Barone, D Bonofiglio, ... Journal of cellular physiology 218 (3), 490-500, 2009 | 136 | 2009 |
Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1‐mediated p53 activation G Gu, I Barone, L Gelsomino, C Giordano, D Bonofiglio, G Statti, ... Journal of cellular physiology 227 (10), 3363-3372, 2012 | 93 | 2012 |
Rapid estradiol/ERα signaling enhances aromatase enzymatic activity in breast cancer cells S Catalano, I Barone, C Giordano, P Rizza, H Qi, G Gu, R Malivindi, ... Molecular endocrinology 23 (10), 1634-1645, 2009 | 91 | 2009 |
ESR1 mutations affect anti-proliferative responses to tamoxifen through enhanced cross-talk with IGF signaling L Gelsomino, G Gu, Y Rechoum, AR Beyer, SM Pejerrey, A Tsimelzon, ... Breast cancer research and treatment 157, 253-265, 2016 | 88 | 2016 |
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells S Catalano, R Malivindi, C Giordano, G Gu, S Panza, D Bonofiglio, ... Journal of biological chemistry 285 (8), 5581-5593, 2010 | 72 | 2010 |
Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α I Barone, L Brusco, G Gu, J Selever, A Beyer, KR Covington, A Tsimelzon, ... Journal of the National Cancer Institute 103 (7), 538-552, 2011 | 63 | 2011 |
Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells J Selever, G Gu, MT Lewis, A Beyer, MH Herynk, KR Covington, ... Clinical Cancer Research 17 (20), 6510-6521, 2011 | 62 | 2011 |
Androgen receptor promotes tamoxifen agonist activity by activation of EGFR in ERα-positive breast cancer A Ciupek, Y Rechoum, G Gu, L Gelsomino, AR Beyer, L Brusco, ... Breast cancer research and treatment 154, 225-237, 2015 | 61 | 2015 |
Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets LA Gates, G Gu, Y Chen, AD Rohira, JT Lei, RA Hamilton, Y Yu, ... Oncogene 37 (33), 4581-4598, 2018 | 60 | 2018 |
Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines L Gelsomino, S Panza, C Giordano, I Barone, G Gu, E Spina, S Catalano, ... Cancer letters 428, 12-20, 2018 | 55 | 2018 |
The Impact of ESR1 Mutations on the Treatment of Metastatic Breast Cancer SM Pejerrey, D Dustin, JA Kim, G Gu, Y Rechoum, SAW Fuqua Hormones and Cancer 9, 215-228, 2018 | 45 | 2018 |
Targeting thyroid hormone receptor beta in triple-negative breast cancer G Gu, L Gelsomino, KR Covington, AR Beyer, J Wang, Y Rechoum, ... Breast cancer research and treatment 150, 535-545, 2015 | 43 | 2015 |
Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol “in situ” production S Catalano, P Rizza, G Gu, I Barone, C Giordano, S Marsico, I Casaburi, ... Journal of cellular physiology 211 (2), 448-456, 2007 | 31 | 2007 |
Hormonal modulation of ESR1 mutant metastasis G Gu, L Tian, SK Herzog, Y Rechoum, L Gelsomino, M Gao, L Du, JA Kim, ... Oncogene 40 (5), 997-1011, 2021 | 26 | 2021 |
The SMRT coregulator enhances growth of estrogen receptor-α-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis JK Blackmore, S Karmakar, G Gu, V Chaubal, L Wang, W Li, CL Smith Endocrinology 155 (9), 3251-3261, 2014 | 23 | 2014 |
ESR1 Mutations in Breast Cancer: Proof-of-Concept Challenges Clinical Action G Gu, SAW Fuqua Clinical Cancer Research 22 (5), 1034-1036, 2016 | 19 | 2016 |
Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity F Stossi, RD Dandekar, MG Mancini, G Gu, SAW Fuqua, A Nardone, ... Nucleic acids research 48 (4), 1800-1810, 2020 | 18 | 2020 |