Noel Southall
Noel Southall
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A view of the hydrophobic effect
NT Southall, KA Dill, ADJ Haymet
The Journal of Physical Chemistry B 106 (3), 521-533, 2002
How ions affect the structure of water
B Hribar, NT Southall, V Vlachy, KA Dill
Journal of the American Chemical Society 124 (41), 12302-12311, 2002
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
R Huang, N Southall, Y Wang, A Yasgar, P Shinn, A Jadhav, DT Nguyen, ...
Science translational medicine 3 (80), 80ps16-80ps16, 2011
COPI complex is a regulator of lipid homeostasis
M Beller, C Sztalryd, N Southall, M Bell, DS Jš ckle, H., Auld, B Oliver
PLoS Biol 6, e292, 2008
Compound cytotoxicity profiling using quantitative high-throughput screening
M Xia, R Huang, KL Witt, N Southall, J Fostel, MH Cho, A Jadhav, ...
Environmental health perspectives 116 (3), 284-291, 2008
Unexplored therapeutic opportunities in the human genome
TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ...
Nature reviews Drug discovery 17 (5), 317-332, 2018
Fluorescence spectroscopic profiling of compound libraries
A Simeonov, A Jadhav, CJ Thomas, Y Wang, R Huang, NT Southall, ...
Journal of medicinal chemistry 51 (8), 2363-2371, 2008
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis
M Samie, X Wang, X Zhang, A Goschka, X Li, X Cheng, E Gregg, M Azar, ...
Developmental cell 26 (5), 511-524, 2013
The mechanism of hydrophobic solvation depends on solute radius
NT Southall, KA Dill
The Journal of Physical Chemistry B 104 (6), 1326-1331, 2000
The mechanism of hydrophobic solvation depends on solute radius
NT Southall, KA Dill
The Journal of Physical Chemistry B 104 (6), 1326-1331, 2000
Characterization of chemical libraries for luciferase inhibitory activity
DS Auld, NT Southall, A Jadhav, RL Johnson, DJ Diller, A Simeonov, ...
Journal of medicinal chemistry 51 (8), 2372-2386, 2008
Pharos: collating protein information to shed light on the druggable genome
DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, ...
Nucleic acids research 45 (D1), D995-D1002, 2017
Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome
GW Rhyasen, L Bolanos, J Fang, A Jerez, M Wunderlich, C Rigolino, ...
Cancer cell 24 (1), 90-104, 2013
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
W Wang, Q Gao, M Yang, X Zhang, LU Yu, M Lawas, X Li, ...
Proceedings of the National Academy of Sciences 112 (11), E1373-E1381, 2015
Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase
MB Boxer, J Jiang, MG Vander Heiden, M Shen, AP Skoumbourdis, ...
Journal of medicinal chemistry 53 (3), 1048-1055, 2010
High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer
A Datta, H Kim, L McGee, AE Johnson, S Talwar, J Marugan, N Southall, ...
Scientific reports 8 (1), 1-13, 2018
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries
H Veith, N Southall, R Huang, T James, D Fayne, N Artemenko, M Shen, ...
Nature biotechnology 27 (11), 1050-1055, 2009
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders
M Xu, K Liu, M Swaroop, FD Porter, R Sidhu, S Finkes, DS Ory, ...
Journal of Biological Chemistry 287 (47), 39349-39360, 2012
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
S He, B Lin, V Chu, Z Hu, X Hu, J Xiao, AQ Wang, CJ Schweitzer, Q Li, ...
Science translational medicine 7 (282), 282ra49-282ra49, 2015
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