Chen-Hsiang Shen
Chen-Hsiang Shen
Vaccine Research Center, NIAID
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Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses
MG Joyce, AK Wheatley, PV Thomas, GY Chuang, C Soto, RT Bailer, ...
Cell 166 (3), 609-623, 2016
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
K Xu, P Acharya, R Kong, C Cheng, GY Chuang, K Liu, MK Louder, ...
doi:, 2018
Quantification of the impact of the HIV-1-glycan shield on antibody elicitation
T Zhou, NA Doria-Rose, C Cheng, GBE Stewart-Jones, GY Chuang, ...
Cell reports 19 (4), 719-732, 2017
Amprenavir complexes with HIV‐1 protease and its drug‐resistant mutants altering hydrophobic clusters
CH Shen, YF Wang, AY Kovalevsky, RW Harrison, IT Weber
The FEBS journal 277 (18), 3699-3714, 2010
HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements
J Agniswamy, CH Shen, A Aniana, JM Sayer, JM Louis, IT Weber
Biochemistry 51 (13), 2819-2828, 2012
Antibody lineages with vaccine-induced antigen-binding hotspots develop broad HIV neutralization
R Kong, H Duan, Z Sheng, K Xu, P Acharya, X Chen, C Cheng, ...
Cell 178 (3), 567-584. e19, 2019
PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine
R Rawi, R Mall, K Kunji, CH Shen, PD Kwong, GY Chuang
Bioinformatics 34 (7), 1092-1098, 2018
A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope
T Zhou, A Zheng, U Baxa, GY Chuang, IS Georgiev, R Kong, S O’Dell, ...
Immunity 48 (3), 500-513. e6, 2018
Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure
Z Chen, G Diaz, T Pollicino, H Zhao, RE Engle, P Schuck, CH Shen, ...
Proceedings of the National Academy of Sciences 115 (48), E11369-E11378, 2018
Structural survey of broadly neutralizing antibodies targeting the HIV-1 Env trimer delineates epitope categories and characteristics of recognition
GY Chuang, J Zhou, P Acharya, R Rawi, CH Shen, Z Sheng, B Zhang, ...
Structure 27 (1), 196-206. e6, 2019
Longitudinal analysis reveals early development of three MPER-directed neutralizing antibody lineages from an HIV-1-infected individual
SJ Krebs, YD Kwon, CA Schramm, WH Law, G Donofrio, KH Zhou, S Gift, ...
Immunity 50 (3), 677-691. e13, 2019
Long‐range electrostatics‐induced two‐proton transfer captured by neutron crystallography in an enzyme catalytic site
O Gerlits, T Wymore, A Das, CH Shen, JM Parks, JC Smith, KL Weiss, ...
Angewandte Chemie 128 (16), 5008-5011, 2016
Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1′-pyrrolidinone or P2-tris-tetrahydrofuran
J Agniswamy, CH Shen, YF Wang, AK Ghosh, KV Rao, CX Xu, JM Sayer, ...
Journal of medicinal chemistry 56 (10), 4017-4027, 2013
Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease
H Zhang, YF Wang, CH Shen, J Agniswamy, KV Rao, CX Xu, AK Ghosh, ...
Journal of medicinal chemistry 56 (3), 1074-1083, 2013
Paired heavy-and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses
BB Banach, G Cerutti, AS Fahad, CH Shen, MO De Souza, PS Katsamba, ...
Cell reports 37 (1), 109771, 2021
Structure of super-potent antibody CAP256-VRC26. 25 in complex with HIV-1 envelope reveals a combined mode of trimer-apex recognition
J Gorman, GY Chuang, YT Lai, CH Shen, JC Boyington, A Druz, H Geng, ...
Cell reports 31 (1), 107488, 2020
Automated prediction of HIV drug resistance from genotype data
RWHITW ChenHsiang Shen, Xiaxia Yu
BMC Bioinformatics 17 (Suppl 8), 278, 2016
Homocysteine, vitamin B6, and lipid in cardiovascular disease
SJ Chan, CN Chang, JC Hsu, YS Lee, CH Shen
Nutrition 18 (7-8), 595-598, 2002
Conformational variation of an extreme drug resistant mutant of HIV protease
CH Shen, YC Chang, J Agniswamy, RW Harrison, IT Weber
Journal of Molecular Graphics and Modelling 62, 87-96, 2015
Improvement of antibody functionality by structure-guided paratope engraftment
Q Liu, YT Lai, P Zhang, MK Louder, A Pegu, R Rawi, M Asokan, X Chen, ...
Nature communications 10 (1), 1-13, 2019
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