| Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness S Khare, AS Nagle, A Biggart, YH Lai, F Liang, LC Davis, SW Barnes, ... Nature 537 (7619), 229-233, 2016 | 401 | 2016 |
| Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy KK Ojo, JR Gillespie, AJ Riechers, AJ Napuli, CLMJ Verlinde, FS Buckner, ... Antimicrobial agents and chemotherapy 52 (10), 3710-3717, 2008 | 110 | 2008 |
| Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies TL Arakaki, FS Buckner, JR Gillespie, NA Malmquist, MA Phillips, ... Molecular microbiology 68 (1), 37-50, 2008 | 95 | 2008 |
| Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei infection in mice S Shibata, JR Gillespie, AM Kelley, AJ Napuli, Z Zhang, KV Kovzun, ... Antimicrobial agents and chemotherapy 55 (5), 1982-1989, 2011 | 89 | 2011 |
| Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis HB Tatipaka, JR Gillespie, AK Chatterjee, NR Norcross, MA Hulverson, ... Journal of medicinal chemistry 57 (3), 828-835, 2014 | 78 | 2014 |
| Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection CY Koh, JE Kim, S Shibata, RM Ranade, M Yu, J Liu, JR Gillespie, ... Structure 20 (10), 1681-1691, 2012 | 72 | 2012 |
| Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization S Shibata, JR Gillespie, RM Ranade, CY Koh, JE Kim, JU Laydbak, ... Journal of medicinal chemistry 55 (14), 6342-6351, 2012 | 66 | 2012 |
| C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins JR Gillespie, K Yokoyama, K Lu, RT Eastman, JG Bollinger, ... Molecular and biochemical parasitology 153 (2), 115-124, 2007 | 63 | 2007 |
| Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis. TRR Patrick DA, Gillespie JR, McQueen J, Hulverson MA, Ranade RM, Creason SA ... j. med. chem 60 (3), 957-971, 2016 | 58* | 2016 |
| Optimization of methionyl tRNA-synthetase inhibitors for treatment of Cryptosporidium infection FS Buckner, RM Ranade, JR Gillespie, S Shibata, MA Hulverson, Z Zhang, ... Antimicrob Agents Chemother., 2019 | 41 | 2019 |
| Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness CY Koh, JE Kim, AB Wetzel, WJ de van der Schueren, S Shibata, ... PLOS Neglected Tropical Diseases 8 (4), 2014 | 41 | 2014 |
| Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs EA Merritt, TL Arakaki, JR Gillespie, ET Larson, A Kelley, N Mueller, ... Journal of molecular biology 397 (2), 481-494, 2010 | 38 | 2010 |
| Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors EG Hankins, JR Gillespie, K Aikenhead, FS Buckner Molecular and biochemical parasitology 144 (1), 68-75, 2005 | 38 | 2005 |
| 1-Benzyl-3-aryl-2-thiohydantoin derivatives as new anti-Trypanosoma brucei agents: SAR and in-vivo efficacy A Buchynskyy, JR Gillespie, ZM Herbst, RM Ranade, B Frederick S., ... ACS Med Chem Letters, 2017 | 37 | 2017 |
| Identification of Potent Inhibitors of the Trypanosoma brucei Methionyl-tRNA Synthetase via High-Throughput Orthogonal Screening L Pedró-Rosa, FS Buckner, RM Ranade, C Eberhart, F Madoux, ... J Biomol Screen, 2014 | 37 | 2014 |
| Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections O Faghih, Z Zhang, RM Ranade, JR Gillespie, SA Creason, W Huang, ... Antimicrobial Agents and Chemotherapy 61 (11), 10.1128/aac. 00999-17, 2017 | 32 | 2017 |
| 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors Z Zhang, CY Koh, RM Ranade, S Shibata, JR Gillespie, MA Hulverson, ... ACS Infectious Diseases 2 (6), 399-404, 2016 | 32 | 2016 |
| Structure-guided design of novel Trypanosoma brucei methionyl-tRNA synthetase inhibitors W Huang, Z Zhang, X Barros-Álvarez, CY Koh, RM Ranade, JR Gillespie, ... European journal of medicinal chemistry 124, 1081-1092, 2016 | 28 | 2016 |
| Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target RM Ranade, JR Gillespie, S Shibata, CLMJ Verlinde, E Fan, WGJ Hol, ... Antimicrobial agents and chemotherapy 57 (7), 3021-3028, 2013 | 26 | 2013 |
| A new Class of Antitrypanosomal Agents Based on Imidazopyridines DG Silva, JR Gillespie, RM Ranade, ZM Herbst, U Nguyen, FS Buckner, ... ACS Med. Chem. Lett, 2017 | 25 | 2017 |
Christophe LMJ VerlindeAssociate professor of Biochemistry, University of Washington, SeattleVerified email at u.washington.edu
