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Nikhil Pillai
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Machine learning guided early drug discovery of small molecules
N Pillai, A Dasgupta, S Sudsakorn, J Fretland, PD Mavroudis
Drug Discovery Today 27 (8), 2209-2215, 2022
282022
Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search
N Pillai, SL Schwartz, T Ho, A Dokoumetzidis, R Bies, I Freedman
Journal of pharmacokinetics and pharmacodynamics 46, 193-210, 2019
232019
Development of a genetic algorithm and NONMEM workbench for automating and improving population pharmacokinetic/pharmacodynamic model selection
M Ismail, M Sale, Y Yu, N Pillai, S Liu, B Pflug, R Bies
Journal of Pharmacokinetics and Pharmacodynamics, 1-14, 2022
152022
Model-guided antipsychotic dose reduction in schizophrenia: a pilot, single-blind randomized controlled trial
C Ozawa, RR Bies, N Pillai, T Suzuki, M Mimura, H Uchida
Journal of clinical psychopharmacology 39 (4), 329-335, 2019
152019
Circadian patterns of hallucinatory experiences in patients with schizophrenia: potentials for chrono-pharmacology
T Koizumi, T Suzuki, NS Pillai, RR Bies, H Takeuchi, K Yoshimura, ...
Journal of psychiatric research 117, 1-6, 2019
82019
Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: Estimating tumor antigenicity in a model of immunotherapy
N Pillai, M Craig, A Dokoumetzidis, SL Schwartz, R Bies, I Freedman
Progress in biophysics and molecular biology 139, 23-30, 2018
82018
Investigation on airfoil operating in Ground Effect region
NS Pillai, T Anil, R Aravind, R Vinod, E Sudheesh Kumer, ZU Zaid, ...
International Journal of Engineering & Technology 3 (4), 540-544, 2014
62014
Application of machine learning in combination with mechanistic modeling to predict plasma exposure of small molecules
PD Mavroudis, D Teutonico, A Abos, N Pillai
Frontiers in Systems Biology 3, 1180948, 2023
22023
A machine learning, genetic algorithm based approach to model selection for tumor growth
S Liu, M Ismail, NS Pillai, B Pflug, M Sale, R Bies
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 45, S46-S46, 2018
22018
A multi‐model approach to predict efficacious clinical dose for an anti‐TGF‐β antibody (GC2008) in the treatment of osteogenesis imperfecta
PD Mavroudis, N Pillai, Q Wang, C Pouzin, B Greene, J Fretland
CPT: Pharmacometrics & Systems Pharmacology 11 (11), 1485-1496, 2022
12022
Population analysis of castrate resistant prostate cancer tumor trajectories with modulation of translocation protein function
NS Pillai, B Pflug, H Dai, RR Bies
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 85 (7), 1633-1634, 2019
12019
A minimal physiologically based pharmacokinetic model to study the combined effect of antibody size, charge, and binding affinity to FcRn/antigen on antibody pharmacokinetics
K Patidar, N Pillai, S Dhakal, LB Avery, PD Mavroudis
Journal of Pharmacokinetics and Pharmacodynamics, 1-16, 2024
2024
Treatment of osteogenesis imperfecta
PD Mavroudis, N Pillai, Q Wang
US Patent App. 18/051,468, 2023
2023
MICROBIOME-MEDIATED CHECKPOINT INHIBITION IDENTIFIED TO AFFECT VACCINE HYPORESPONSE IN THE ELDERLY USING MACHINE LEARNING AND QUANTITATIVE SYSTEMS PHARMACOLOGY (QSP).
C Cho, S Hayes, N Pillai, P Bloomingdale, J Ryman, J Sachs
CLINICAL PHARMACOLOGY & THERAPEUTICS 107, S73-S73, 2020
2020
Optimization Algorithm to Determine Parameters and Track Nonlinear Dynamic Systems in Pharmacology
NS Pillai
State University of New York at Buffalo, 2020
2020
Estimating parameters of chaotic systems: chaos synchronization combined with Nelder-Mead search
N Pillai
PAGE, 2018
2018
Grid Search And Chaos Synchronization As A Tool To Uniquely Estimate Parameters Of A Chaotic Pharmacological System
N Pillai, SL Schwartz, T Ho, A Dokoumetzidis, R Bies, I Freedman
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 44, S102-S102, 2017
2017
Modeling Post-Impact Injury Propagation in Traumatic Brain Injury
N Pillai, A Patra, E Esfahani
International Design Engineering Technical Conferences and Computers and …, 2016
2016
Simple Advection Based Model for Predicting Injury Progression in Traumatic Brain Injury
NS Pillai
State University of New York at Buffalo, 2016
2016
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Articles 1–19