| Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors TO Fischmann, CK Smith, TW Mayhood, JE Myers Jr, P Reichert, ... Biochemistry 48 (12), 2661-2674, 2009 | 204 | 2009 |
| Drug Delivery Systems. 2. Camptothecin 20-O-Poly(ethylene glycol) Ester Transport Forms RB Greenwald, A Pendri, C Conover, C Gilbert, R Yang, J Xia Journal of Medicinal Chemistry 39 (10), 1938-1940, 1996 | 142 | 1996 |
| Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl … AJ Prongay, Z Guo, N Yao, J Pichardo, T Fischmann, C Strickland, ... Journal of medicinal chemistry 50 (10), 2310-2318, 2007 | 124 | 2007 |
| Profiling active enzymes for polysorbate degradation in biotherapeutics by activity-based protein profiling X Li, D Chandra, S Letarte, GC Adam, J Welch, RS Yang, S Rivera, ... Analytical Chemistry 93 (23), 8161-8169, 2021 | 34 | 2021 |
| A novel arylsulfatase A protein variant and genotype in two patients with major depression MH Ricketts, JD Amsterdam, DS Park, RS Yang, RD Poretz, X Zhang, ... Journal of affective disorders 40 (3), 137-147, 1996 | 14 | 1996 |
| The structural basis for the electrophoretic isoforms of normal and variant human platelet arylsulphatase A RD Poretz, RS Yang, B Canas, H Lackland, S Stein, P Manowitz Biochemical Journal 287 (3), 979-983, 1992 | 13 | 1992 |
| Applications of TiCl3 as a Diagnostic Reagent for the Detection of Nitro- and N-Oxide-Containing Compounds as Potentially Mutagenic Impurities Using Ultrahigh … RS Yang, A Beard, H Sheng, LK Zhang, R Helmy Organic Process Research & Development 20 (1), 59-64, 2016 | 11 | 2016 |
| Characterization of impurities of HIV NNRTI Doravirine by UHPLC‐high resolution MS and tandem MS analysis LK Zhang, R Yang, H Sheng, R Helmy, J Zheng, Y Cao, DR Gauthier Jr Journal of mass spectrometry 51 (10), 959-968, 2016 | 9 | 2016 |
| Extensive characterization of polysorbate 80 oxidative degradation under stainless steel conditions X Zheng, AT Sutton, RS Yang, DV Miller, B Pagels, RR Rustandi, J Welch, ... Journal of Pharmaceutical Sciences 112 (3), 779-789, 2023 | 8 | 2023 |
| Advancing structure characterization of PS-80 by charge-reduced mass spectrometry and software-assisted composition analysis RS Yang, DR Bush, N DeGraan-Weber, D Barbacci, LK Zhang, S Letarte, ... Journal of Pharmaceutical Sciences 111 (2), 314-322, 2022 | 8 | 2022 |
| Unexpected Propargylic Retro-Brook Rearrangements in Alkynes X Wang, Q Gao, AV Buevich, N Yasuda, Y Zhang, RS Yang, LK Zhang, ... The Journal of Organic Chemistry 84 (16), 10024-10031, 2019 | 8 | 2019 |
| Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan WL Cheung‐Lee, JN Kolev, JA McIntosh, AA Gil, W Pan, L Xiao, ... Angewandte Chemie International Edition 63 (13), e202316133, 2024 | 7 | 2024 |
| Mechanistic study of the gas-phase in-source Hofmann elimination of doubly quaternized cinchona-alkaloid based phase-transfer catalysts by (+)-electrospray ionization/tandem … RS Yang, H Sheng, KW Lexa, EC Sherer, LK Zhang, B Xiang, R Helmy, ... Journal of The American Society for Mass Spectrometry 28 (3), 452-460, 2017 | 7 | 2017 |
| A tiered approach for characterization to ensure quality, reproducibility, and long-term stability of critical reagents in regulated bioanalysis to support PK/ADA/NAb assays … K Yang, Y Zhang, R Chou, L Yeung, S Letarte, RS Yang, X Li, ... ACS Pharmacology & Translational Science 3 (6), 1310-1317, 2020 | 6 | 2020 |
| Low-molecular-weight impurity in Poloxamer 188 responsible for atypical cell culture performance for mAb production A Bandyopadhyay, H Kosanam, RS Yang, B Gupta, N Naralakattu, ... Journal of Biotechnology 351, 13-22, 2022 | 3 | 2022 |
| Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034 V Madison, AJ Prongay, Z Guo, N Yao, J Pichardo, T Fischmann, ... Journal of Synchrotron Radiation 15 (3), 204-207, 2008 | 3 | 2008 |
| Development of a highly efficient decontamination approach for ceftolozane in the pharmaceutical manufacturing environment RS Yang, LK Zhang, R Helmy, T Andreani, Z Liu, H Sheng Journal of pharmaceutical and biomedical analysis 177, 112846, 2020 | 2 | 2020 |
| Rapid characterization of insulin modifications and sequence variations by proteinase K digestion and UHPLC-ESI-MS RS Yang, W Tang, H Sheng, F Meng Journal of The American Society for Mass Spectrometry 29 (5), 853-858, 2018 | 2 | 2018 |
| Unusual (+/–)‐electrospray ionization induced fragmentation: Structural elucidation of an in‐process synthetic intermediate of doravirine (MK‐1439) using liquid chromatography … H Sheng, KW Lexa, LK Zhang, RS Yang, TJ Wright, BD Sherry, R Helmy, ... Rapid Communications in Mass Spectrometry 31 (8), 719-727, 2017 | 1 | 2017 |
| Mechanistic Insight into the Oxazoline Decomposition of DFC-M, a Synthetic Intermediate of Florfenicol RS Yang, X Wang, WeijuanTang, C Celly, H Sheng Journal of Pharmaceutical and Biomedical Analysis 174 (10), 235-241, 2019 | | 2019 |
Li-Kang H. ZhangMerck, Schering-Plough, Washington Univ. in St. LouisVerified email at merck.com
