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Lesley Mathews
Lesley Mathews
Verified email at novartis.com
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Cited by
Cited by
Year
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
Y Yang, AL Shaffer III, NCT Emre, M Ceribelli, M Zhang, G Wright, W Xiao, ...
Cancer cell 21 (6), 723-737, 2012
5242012
Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with …
MM Mita, AC Mita, QS Chu, EK Rowinsky, GJ Fetterly, M Goldston, ...
Journal of Clinical Oncology 26 (3), 361-367, 2008
3022008
The cancer stem cell niche—there goes the neighborhood?
SM Cabarcas, LA Mathews, WL Farrar
International journal of cancer 129 (10), 2315-2327, 2011
2592011
Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature
GJ Klarmann, EM Hurt, LA Mathews, X Zhang, MA Duhagon, T Mistree, ...
Clinical & experimental metastasis 26 (5), 433-446, 2009
2462009
Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome
GW Rhyasen, L Bolanos, J Fang, A Jerez, M Wunderlich, C Rigolino, ...
Cancer cell 24 (1), 90-104, 2013
1852013
Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer
F Crea, EM Hurt, LA Mathews, SM Cabarcas, L Sun, VE Marquez, ...
Molecular cancer 10 (1), 1-10, 2011
1852011
Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells
L Sun, LA Mathews, SM Cabarcas, X Zhang, A Yang, Y Zhang, MR Young, ...
Stem cells 31 (8), 1454-1466, 2013
1292013
Epigenetic gene regulation in stem cells and correlation to cancer
LA Mathews, F Crea, WL Farrar
Differentiation 78 (1), 1-17, 2009
872009
Increased expression of DNA repair genes in invasive human pancreatic cancer cells
LA Mathews, SM Cabarcas, EM Hurt, X Zhang, EM Jaffee, WL Farrar
Pancreas 40 (5), 730, 2011
832011
Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-β-dependent pathways
KA Becker, S Lu, ES Dickinson, KA Dunphy, L Mathews, SS Schneider, ...
Oncogene 24 (42), 6345-6353, 2005
512005
DNA repair: the culprit for tumor-initiating cell survival?
LA Mathews, SM Cabarcas, WL Farrar
Cancer and metastasis reviews 30 (2), 185-197, 2011
462011
Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins
L Casson, L Howell, LA Mathews, M Ferrer, N Southall, R Guha, JM Keller, ...
PLoS One 8 (1), e54525, 2013
452013
Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells
LA Mathews, EM Hurt, X Zhang, WL Farrar
Molecular cancer 9 (1), 1-17, 2010
402010
Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity
S Lu, KA Becker, MJ Hagen, H Yan, AL Roberts, LA Mathews, ...
Endocrinology 149 (10), 4809-4820, 2008
382008
A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells
LA Mathews, JM Keller, BL Goodwin, R Guha, P Shinn, R Mull, ...
Journal of biomolecular screening 17 (9), 1231-1242, 2012
362012
Targeting prostate cancer stem cells
F Crea, LA Mathews, WL Farrar, EM Hurt
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2009
322009
DNA repair of cancer stem cells
LA Mathews, SM Cabarcas, EM Hurt
Springer, 2013
282013
Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression
Y Zhang, SM Cabarcas, JI Zheng, L Sun, LA Mathews, X Zhang, H Lin, ...
Oncology Letters 11 (6), 3803-3812, 2016
142016
Multiplexing High‐Content Flow (HCF) and Quantitative High‐Throughput Screening (qHTS) to Identify Compounds Capable of Decreasing Cell Viability, Activating Caspase 3/7 …
LA Mathews, JM Keller, C McKnight, S Michael, P Shinn, D Liu, LM Staudt, ...
Current Protocols in Chemical Biology 5 (3), 195-212, 2013
72013
The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by cilengitide
SM Cabarcas, L Sun, L Mathews, S Thomas, X Zhang, WL Farrar
Pancreas 42 (5), 861, 2013
72013
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