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Florian Nachon
Florian Nachon
Institut de Recherche Biomédicale des Armées
Verified email at irba.fr
Title
Cited by
Cited by
Year
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
Y Nicolet, O Lockridge, P Masson, JC Fontecilla-Camps, F Nachon
Journal of Biological Chemistry 278 (42), 41141-41147, 2003
8992003
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl-and butyryl-cholinesterase
F Nachon, E Carletti, C Ronco, M Trovaslet, Y Nicolet, L Jean, PY Renard
Biochemical Journal 453 (3), 393-399, 2013
3812013
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
G Mercey, T Verdelet, J Renou, M Kliachyna, R Baati, F Nachon, L Jean, ...
Accounts of chemical research 45 (5), 756-766, 2012
3812012
Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study
TL Rosenberry, X Brazzolotto, IR Macdonald, M Wandhammer, ...
Molecules 22 (12), 2098, 2017
2122017
Progress in the development of enzyme-based nerve agent bioscavengers
F Nachon, X Brazzolotto, M Trovaslet, P Masson
Chemico-biological interactions 206 (3), 536-544, 2013
1812013
Engineering of a monomeric and low‐glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization
F Nachon, Y Nicolet, N Viguié, P Masson, JC Fontecilla‐Camps, ...
European Journal of Biochemistry 269 (2), 630-637, 2002
1682002
Discovery and structure–activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening
SN Dighe, GS Deora, E De la Mora, F Nachon, S Chan, MO Parat, ...
Journal of medicinal chemistry 59 (16), 7683-7689, 2016
1372016
The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity
U Kosak, B Brus, D Knez, S Zakelj, J Trontelj, A Pislar, R Sink, M Jukic, ...
Journal of medicinal chemistry 61 (1), 119-139, 2018
1282018
Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation
E Carletti, H Li, B Li, F Ekström, Y Nicolet, M Loiodice, E Gillon, ...
Journal of the American Chemical Society 130 (47), 16011-16020, 2008
1282008
Development of an in-vivo active reversible butyrylcholinesterase inhibitor
U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ...
Scientific reports 6 (1), 39495, 2016
1272016
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
G Mercey, T Verdelet, G Saint-André, E Gillon, A Wagner, R Baati, L Jean, ...
Chemical Communications 47 (18), 5295-5297, 2011
1242011
Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate:  The Crystal Structure Suggests Two Alternative Mechanisms of Aging,
F Nachon, OA Asojo, GEO Borgstahl, P Masson, O Lockridge
Biochemistry 44 (4), 1154-1162, 2005
1212005
Cholinesterase reactivators and bioscavengers for pre‐and post‐exposure treatments of organophosphorus poisoning
P Masson, F Nachon
Journal of neurochemistry 142, 26-40, 2017
1152017
Binding and hydrolysis of soman by human serum albumin
B Li, F Nachon, MT Froment, L Verdier, JC Debouzy, B Brasme, E Gillon, ...
Chemical research in toxicology 21 (2), 421-431, 2008
1152008
Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation
E Carletti, JP Colletier, F Dupeux, M Trovaslet, P Masson, F Nachon
Journal of Medicinal Chemistry 53 (10), 4002-4008, 2010
1132010
Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure
X Brazzolotto, M Wandhammer, C Ronco, M Trovaslet, L Jean, ...
The FEBS journal 279 (16), 2905-2916, 2012
1102012
Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime
B Sanson, F Nachon, JP Colletier, MT Froment, L Toker, HM Greenblatt, ...
Journal of medicinal chemistry 52 (23), 7593-7603, 2009
1092009
Structure, activities and biomedical applications of human butyrylcholinesterase
P Masson, E Carletti, F Nachon
Protein and peptide letters 16 (10), 1215-1224, 2009
1062009
Exposure to tri-o-cresyl phosphate detected in jet airplane passengers
M Liyasova, B Li, LM Schopfer, F Nachon, P Masson, CE Furlong, ...
Toxicology and applied pharmacology 256 (3), 337-347, 2011
1012011
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine-aldoxime and-amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited …
M Kliachyna, G Santoni, V Nussbaum, J Renou, B Sanson, JP Colletier, ...
European journal of medicinal chemistry 78, 455-467, 2014
962014
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