Florian Nachon
Florian Nachon
Institut de Recherche Biomédicale des Armées
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Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
Y Nicolet, O Lockridge, P Masson, JC Fontecilla-Camps, F Nachon
Journal of Biological Chemistry 278 (42), 41141-41147, 2003
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl-and butyryl-cholinesterase
F Nachon, E Carletti, C Ronco, M Trovaslet, Y Nicolet, L Jean, PY Renard
Biochemical Journal 453 (3), 393-399, 2013
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
G Mercey, T Verdelet, J Renou, M Kliachyna, R Baati, F Nachon, L Jean, ...
Accounts of chemical research 45 (5), 756-766, 2012
Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study
TL Rosenberry, X Brazzolotto, IR Macdonald, M Wandhammer, ...
Molecules 22 (12), 2098, 2017
Progress in the development of enzyme-based nerve agent bioscavengers
F Nachon, X Brazzolotto, M Trovaslet, P Masson
Chemico-biological interactions 206 (3), 536-544, 2013
Engineering of a monomeric and low‐glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization
F Nachon, Y Nicolet, N Viguié, P Masson, JC Fontecilla‐Camps, ...
European Journal of Biochemistry 269 (2), 630-637, 2002
Discovery and structure–activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening
SN Dighe, GS Deora, E De la Mora, F Nachon, S Chan, MO Parat, ...
Journal of medicinal chemistry 59 (16), 7683-7689, 2016
The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity
U Kosak, B Brus, D Knez, S Zakelj, J Trontelj, A Pislar, R Sink, M Jukic, ...
Journal of medicinal chemistry 61 (1), 119-139, 2018
Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation
E Carletti, H Li, B Li, F Ekström, Y Nicolet, M Loiodice, E Gillon, ...
Journal of the American Chemical Society 130 (47), 16011-16020, 2008
Development of an in-vivo active reversible butyrylcholinesterase inhibitor
U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ...
Scientific reports 6 (1), 39495, 2016
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
G Mercey, T Verdelet, G Saint-André, E Gillon, A Wagner, R Baati, L Jean, ...
Chemical Communications 47 (18), 5295-5297, 2011
Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate:  The Crystal Structure Suggests Two Alternative Mechanisms of Aging,
F Nachon, OA Asojo, GEO Borgstahl, P Masson, O Lockridge
Biochemistry 44 (4), 1154-1162, 2005
Cholinesterase reactivators and bioscavengers for pre‐and post‐exposure treatments of organophosphorus poisoning
P Masson, F Nachon
Journal of neurochemistry 142, 26-40, 2017
Binding and hydrolysis of soman by human serum albumin
B Li, F Nachon, MT Froment, L Verdier, JC Debouzy, B Brasme, E Gillon, ...
Chemical research in toxicology 21 (2), 421-431, 2008
Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation
E Carletti, JP Colletier, F Dupeux, M Trovaslet, P Masson, F Nachon
Journal of Medicinal Chemistry 53 (10), 4002-4008, 2010
Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure
X Brazzolotto, M Wandhammer, C Ronco, M Trovaslet, L Jean, ...
The FEBS journal 279 (16), 2905-2916, 2012
Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime
B Sanson, F Nachon, JP Colletier, MT Froment, L Toker, HM Greenblatt, ...
Journal of medicinal chemistry 52 (23), 7593-7603, 2009
Structure, activities and biomedical applications of human butyrylcholinesterase
P Masson, E Carletti, F Nachon
Protein and peptide letters 16 (10), 1215-1224, 2009
Exposure to tri-o-cresyl phosphate detected in jet airplane passengers
M Liyasova, B Li, LM Schopfer, F Nachon, P Masson, CE Furlong, ...
Toxicology and applied pharmacology 256 (3), 337-347, 2011
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine-aldoxime and-amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited …
M Kliachyna, G Santoni, V Nussbaum, J Renou, B Sanson, JP Colletier, ...
European journal of medicinal chemistry 78, 455-467, 2014
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