Mark Henderson
Mark Henderson
National Center for Advancing Translational Sciences
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Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors
MJ Henderson, CT Richie, M Airavaara, Y Wang, BK Harvey
Journal of Biological Chemistry 288 (6), 4209-4225, 2013
GCF2/LRRFIP1 represses tumor necrosis factor alpha expression
AR Suriano, AN Sanford, N Kim, M Oh, S Kennedy, MJ Henderson, ...
Molecular and cellular biology 25 (20), 9073-9081, 2005
KDM5 histone demethylases repress immune response via suppression of STING
L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, ...
PLoS biology 16 (8), e2006134, 2018
Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds
JR Horton, X Liu, M Gale, L Wu, JR Shanks, X Zhang, PJ Webber, ...
Cell chemical biology 23 (7), 769-781, 2016
Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats
DJ Calu, AB Kawa, NJ Marchant, BM Navarre, MJ Henderson, B Chen, ...
Journal of Neuroscience 33 (1), 214-226, 2013
KDEL receptors are differentially regulated to maintain the ER proteome under calcium deficiency
KA Trychta, S Bäck, MJ Henderson, BK Harvey
Cell reports 25 (7), 1829-1840. e6, 2018
A low affinity GCaMP3 variant (GCaMPer) for imaging the endoplasmic reticulum calcium store
MJ Henderson, HA Baldwin, CA Werley, S Boccardo, LR Whitaker, X Yan, ...
PLoS One 10 (10), e0139273, 2015
A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase
NJ Martinez, RR Asawa, MG Cyr, A Zakharov, DJ Urban, JS Roth, ...
Scientific reports 8 (1), 1-16, 2018
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays
DJ Urban, NJ Martinez, MI Davis, KR Brimacombe, DM Cheff, TD Lee, ...
Scientific reports 7 (1), 12758, 2017
SERCaMP: a carboxy-terminal protein modification that enables monitoring of ER calcium homeostasis
MJ Henderson, ES Wires, KA Trychta, CT Richie, BK Harvey
Molecular biology of the cell 25 (18), 2828-2839, 2014
Ipomoeassin F binds Sec61α to inhibit protein translocation
G Zong, Z Hu, S O’keefe, D Tranter, MJ Iannotti, L Baron, B Hall, ...
Journal of the American Chemical Society 141 (21), 8450-8461, 2019
The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small molecules
K Gorshkov, CZ Chen, R Bostwick, L Rasmussen, BN Tran, YS Cheng, ...
ACS infectious diseases 7 (6), 1389-1408, 2020
High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver
ES Wires, KA Trychta, S Bäck, A Sulima, KC Rice, BK Harvey
Journal of hepatology 67 (5), 1009-1017, 2017
Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice
KD MacDonald, KR McKenzie, MJ Henderson, CE Hawkins, N Vij, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 295 (5 …, 2008
Design, synthesis, and biological evaluation of quinazolin-4-one-based hydroxamic acids as dual PI3K/HDAC inhibitors
A Thakur, GJ Tawa, MJ Henderson, C Danchik, S Liu, P Shah, AQ Wang, ...
Journal of medicinal chemistry 63 (8), 4256-4292, 2020
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2
NP Coussens, SC Kales, MJ Henderson, OW Lee, KY Horiuchi, Y Wang, ...
Journal of Biological Chemistry 293 (35), 13750-13765, 2018
Canvass: A crowd-sourced, natural-product screening library for exploring biological space
SE Kearney, G Zahoránszky-Kőhalmi, KR Brimacombe, MJ Henderson, ...
ACS central science 4 (12), 1727-1741, 2018
Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus
Y Zhong, J Wang, MJ Henderson, P Yang, BM Hagen, T Siddique, ...
Elife 6, e23759, 2017
High-throughput cellular thermal shift assays in research and drug discovery
MJ Henderson, MA Holbert, A Simeonov, LA Kallal
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (2), 137-147, 2020
Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome
SJ Park, Y Kim, SM Yang, MJ Henderson, W Yang, M Lindahl, F Urano, ...
Proceedings of the National Academy of Sciences 116 (28), 14154-14163, 2019
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