Nicolas Coquelle
Nicolas Coquelle
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The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril
E Tayeb-Fligelman, O Tabachnikov, A Moshe, O Goldshmidt-Tran, ...
Science 355 (6327), 831-833, 2017
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor
B Brus, U Kosak, S Turk, A Pislar, N Coquelle, J Kos, J Stojan, JP Colletier, ...
Journal of medicinal chemistry 57 (19), 8167-8179, 2014
Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography
N Coquelle, M Sliwa, J Woodhouse, G Schirò, V Adam, A Aquila, ...
Nature Chemistry 10 (1), 31-37, 2018
Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays
MS Lee, R Green, SM Marsillac, N Coquelle, RS Williams, T Yeung, ...
Cancer research 70 (12), 4880-4890, 2010
Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments
N Coquelle, E Fioravanti, M Weik, F Vellieux, D Madern
Journal of molecular biology 374 (2), 547-562, 2007
Raster-scanning serial protein crystallography using micro-and nano-focused synchrotron beams
N Coquelle, AS Brewster, U Kapp, A Shilova, B Weinhausen, ...
Acta Crystallographica Section D: Biological Crystallography 71 (5), 1184-1196, 2015
An ER‐peroxisome tether exerts peroxisome population control in yeast
B Knoblach, X Sun, N Coquelle, A Fagarasanu, RL Poirier, ...
The EMBO journal 32 (18), 2439-2453, 2013
The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity
U Kosak, B Brus, D Knez, S Zakelj, J Trontelj, A Pislar, R Sink, M Jukic, ...
Journal of medicinal chemistry 61 (1), 119-139, 2018
Development of an in-vivo active reversible butyrylcholinesterase inhibitor
U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ...
Scientific reports 6 (1), 39495, 2016
De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure
JP Colletier, MR Sawaya, M Gingery, JA Rodriguez, D Cascio, ...
Nature 539 (7627), 43-47, 2016
Mechanism and dynamics of fatty acid photodecarboxylase
D Sorigué, K Hadjidemetriou, S Blangy, G Gotthard, A Bonvalet, ...
Science 372 (6538), eabd5687, 2021
Radiation damage and dose limits in serial synchrotron crystallography at cryo-and room temperatures
E de La Mora, N Coquelle, CS Bury, M Rosenthal, JM Holton, ...
Proceedings of the National Academy of Sciences 117 (8), 4142-4151, 2020
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities
D Knez, N Coquelle, A Pišlar, S Žakelj, M Jukič, M Sova, J Mravljak, ...
European journal of medicinal chemistry 156, 598-617, 2018
Slow conformational exchange and overall rocking motion in ubiquitin protein crystals
V Kurauskas, SA Izmailov, ON Rogacheva, A Hessel, I Ayala, ...
Nature communications 8 (1), 145, 2017
Observing the overall rocking motion of a protein in a crystal
P Ma, Y Xue, N Coquelle, JD Haller, T Yuwen, I Ayala, O Mikhailovskii, ...
Nature communications 6 (1), 8361, 2015
Crystallophore: a versatile lanthanide complex for protein crystallography combining nucleating effects, phasing properties, and luminescence
S Engilberge, F Riobé, S Di Pietro, L Lassalle, N Coquelle, CA Arnaud, ...
Chemical science 8 (9), 5909-5917, 2017
Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy
J Woodhouse, G Nass Kovacs, N Coquelle, LM Uriarte, V Adam, ...
Nature communications 11 (1), 741, 2020
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents
U Košak, D Knez, N Coquelle, B Brus, A Pišlar, F Nachon, X Brazzolotto, ...
Bioorganic & medicinal chemistry 25 (2), 633-645, 2017
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents
D Knez, B Brus, N Coquelle, I Sosič, R Šink, X Brazzolotto, J Mravljak, ...
Bioorganic & Medicinal Chemistry 23 (15), 4442-4452, 2015
Gradual adaptive changes of a protein facing high salt concentrations
N Coquelle, R Talon, DH Juers, É Girard, R Kahn, D Madern
Journal of molecular biology 404 (3), 493-505, 2010
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