Matthew Hirschey
Matthew Hirschey
Associate Professor, Duke University
Verified email at - Homepage
Cited by
Cited by
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
MD Hirschey, T Shimazu, E Goetzman, E Jing, B Schwer, DB Lombard, ...
Nature 464 (7285), 121-125, 2010
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor
T Shimazu, MD Hirschey, J Newman, W He, K Shirakawa, N Le Moan, ...
Science 339 (6116), 211-214, 2013
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
X Qiu, K Brown, MD Hirschey, E Verdin, D Chen
Cell metabolism 12 (6), 662-667, 2010
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
DB Lombard, FW Alt, HL Cheng, J Bunkenborg, RS Streeper, ...
Molecular and cellular biology 27 (24), 8807-8814, 2007
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
MD Hirschey, T Shimazu, E Jing, CA Grueter, AM Collins, B Aouizerat, ...
Molecular cell 44 (2), 177-190, 2011
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5
M Tan, C Peng, KA Anderson, P Chhoy, Z Xie, L Dai, J Park, Y Chen, ...
Cell metabolism 19 (4), 605-617, 2014
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
E Verdin, MD Hirschey, LWS Finley, MC Haigis
Trends in biochemical sciences 35 (12), 669-675, 2010
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
E Jing, B Emanuelli, MD Hirschey, J Boucher, KY Lee, D Lombard, ...
Proceedings of the national academy of sciences 108 (35), 14608-14613, 2011
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
T Shimazu, MD Hirschey, L Hua, KE Dittenhafer-Reed, B Schwer, ...
Cell metabolism 12 (6), 654-661, 2010
Metabolic regulation by lysine malonylation, succinylation, and glutarylation
MD Hirschey, Y Zhao
Molecular & Cellular Proteomics 14 (9), 2308-2315, 2015
Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases
GR Wagner, MD Hirschey
Molecular cell 54 (1), 5-16, 2014
Dietary restriction and AMPK increase lifespan via mitochondrial network and peroxisome remodeling
HJ Weir, P Yao, FK Huynh, CC Escoubas, RL Goncalves, K Burkewitz, ...
Cell metabolism 26 (6), 884-896. e5, 2017
Lipids reprogram metabolism to become a major carbon source for histone acetylation
E McDonnell, SB Crown, DB Fox, B Kitir, OR Ilkayeva, CA Olsen, ...
Cell reports 17 (6), 1463-1472, 2016
Dysregulated metabolism contributes to oncogenesis
MD Hirschey, RJ DeBerardinis, AME Diehl, JE Drew, C Frezza, MF Green, ...
Seminars in cancer biology 35, S129-S150, 2015
Designing a broad-spectrum integrative approach for cancer prevention and treatment
KI Block, C Gyllenhaal, L Lowe, A Amedei, ARMR Amin, A Amin, ...
Seminars in cancer biology 35, S276-S304, 2015
Mitochondrial sirtuins
JY Huang, MD Hirschey, T Shimazu, L Ho, E Verdin
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (8), 1645-1651, 2010
The sirtuins, oxidative stress and aging: an emerging link
PI Merksamer, Y Liu, W He, MD Hirschey, D Chen, E Verdin
Aging (Albany NY) 5 (3), 144, 2013
SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion
KA Anderson, FK Huynh, K Fisher-Wellman, JD Stuart, BS Peterson, ...
Cell metabolism 25 (4), 838-855. e15, 2017
SIRT3 regulates progression and development of diseases of aging
E McDonnell, BS Peterson, HM Bomze, MD Hirschey
Trends in Endocrinology & Metabolism 26 (9), 486-492, 2015
Mitochondrial protein acetylation regulates metabolism
KA Anderson, MD Hirschey
Essays in biochemistry 52, 23-35, 2012
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