| Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries J Inglese, DS Auld, A Jadhav, RL Johnson, A Simeonov, A Yasgar, ... Proceedings of the National Academy of Sciences 103 (31), 11473-11478, 2006 | 875 | 2006 |
| The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model A Doran, RS Obach, BJ Smith, NA Hosea, S Becker, E Callegari, C Chen, ... Drug Metabolism and Disposition 33 (1), 165-174, 2005 | 518 | 2005 |
| A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ... Nature chemical biology 12 (6), 452-458, 2016 | 464 | 2016 |
| The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics R Huang, N Southall, Y Wang, A Yasgar, P Shinn, A Jadhav, DT Nguyen, ... Science translational medicine 3 (80), 80ps16-80ps16, 2011 | 423 | 2011 |
| High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells LA Mathews Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, ... Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014 | 403 | 2014 |
| Fluorescence polarization assays in high-throughput screening and drug discovery: a review MD Hall, A Yasgar, T Peryea, JC Braisted, A Jadhav, A Simeonov, ... Methods and applications in fluorescence 4 (2), 022001, 2016 | 216 | 2016 |
| The Tox21 10K compound library: collaborative chemistry advancing toxicology AM Richard, R Huang, S Waidyanatha, P Shinn, BJ Collins, ... Chemical Research in Toxicology 34 (2), 189-216, 2020 | 162 | 2020 |
| AlphaScreen-based assays: ultra-high-throughput screening for small-molecule inhibitors of challenging enzymes and protein-protein interactions A Yasgar, A Jadhav, A Simeonov, NP Coussens High Throughput Screening: Methods and Protocols, 77-98, 2016 | 126 | 2016 |
| Disrupting malaria parasite AMA1–RON2 interaction with a small molecule prevents erythrocyte invasion P Srinivasan, A Yasgar, DK Luci, WL Beatty, X Hu, J Andersen, DL Narum, ... Nature communications 4 (1), 2261, 2013 | 118 | 2013 |
| Compound management for quantitative high-throughput screening A Yasgar, P Shinn, A Jadhav, D Auld, S Michael, W Zheng, CP Austin, ... JALA: Journal of the Association for Laboratory Automation 13 (2), 79-89, 2008 | 108 | 2008 |
| Synthesis and structure–activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl) amino) benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase DK Luci, JB Jameson, A Yasgar, G Diaz, N Joshi, A Kantz, K Markham, ... Journal of medicinal chemistry 57 (2), 495-506, 2014 | 104* | 2014 |
| Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies G Rai, N Joshi, JE Jung, Y Liu, L Schultz, A Yasgar, S Perry, G Diaz, ... Journal of medicinal chemistry 57 (10), 4035-4048, 2014 | 101 | 2014 |
| Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity SM Yang, NJ Martinez, A Yasgar, C Danchik, C Johansson, Y Wang, ... Journal of medicinal chemistry 61 (11), 4883-4903, 2018 | 75 | 2018 |
| Discovery of NCT-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1) SM Yang, A Yasgar, B Miller, M Lal-Nag, K Brimacombe, X Hu, H Sun, ... Journal of medicinal chemistry 58 (15), 5967-5978, 2015 | 60 | 2015 |
| Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor S Titus, S Neumann, W Zheng, N Southall, S Michael, C Klumpp, ... SLAS Discovery 13 (2), 120-127, 2008 | 59 | 2008 |
| Novel consensus architecture to improve performance of large-scale multitask deep learning QSAR models AV Zakharov, T Zhao, DT Nguyen, T Peryea, T Sheils, A Yasgar, R Huang, ... Journal of chemical information and modeling 59 (11), 4613-4624, 2019 | 54 | 2019 |
| Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT–phosphoprotein interaction A Simeonov, A Yasgar, A Jadhav, GL Lokesh, C Klumpp, S Michael, ... Analytical biochemistry 375 (1), 60-70, 2008 | 50 | 2008 |
| 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl … TL Foley, G Rai, A Yasgar, T Daniel, HL Baker, M Attene-Ramos, ... Journal of medicinal chemistry 57 (3), 1063-1078, 2014 | 44 | 2014 |
| Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site M Kasbekar, G Fischer, BT Mott, A Yasgar, M Hyvönen, HIM Boshoff, ... Proceedings of the National Academy of Sciences 113 (27), 7503-7508, 2016 | 42 | 2016 |
| A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase A Yasgar, TL Foley, A Jadhav, J Inglese, MD Burkart, A Simeonov Molecular biosystems 6 (2), 365-375, 2010 | 41 | 2010 |
Anton SimeonovNational Institutes of HealthVerified email at mail.nih.gov
