| The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of type I interferons EC Carroll, L Jin, A Mori, N Munoz-Wolf, E Oleszycka, HBT Moran, ... Immunity 44 (3), 597-608, 2016 | 501 | 2016 |
| MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals L Jin, PM Waterman, KR Jonscher, CM Short, NA Reisdorph, JC Cambier Molecular and cellular biology, 2008 | 455 | 2008 |
| MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic … L Jin, KK Hill, H Filak, J Mogan, H Knowles, B Zhang, AL Perraud, ... The Journal of Immunology 187 (5), 2595-2601, 2011 | 313 | 2011 |
| Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells AS McKee, MA Burchill, MW Munks, L Jin, JW Kappler, RS Friedman, ... Proceedings of the National Academy of Sciences 110 (12), E1122-E1131, 2013 | 171 | 2013 |
| Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production S Roth, A Rottach, AS Lotz-Havla, V Laux, A Muschaweckh, SW Gersting, ... Nature immunology 15 (6), 538-545, 2014 | 164 | 2014 |
| Identification and characterization of a loss-of-function human MPYS variant L Jin, LG Xu, IV Yang, EJ Davidson, DA Schwartz, MM Wurfel, ... Genes & Immunity 12 (4), 263-269, 2011 | 142 | 2011 |
| Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling L Jin, PA McLean, BG Neel, HH Wortis The Journal of experimental medicine 195 (9), 1199-1205, 2002 | 121 | 2002 |
| Deletion of the cyclic di‐AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection J Yang, Y Bai, Y Zhang, VD Gabrielle, L Jin, G Bai Molecular microbiology 93 (1), 65-79, 2014 | 118 | 2014 |
| TMEM173 variants and potential importance to human biology and disease S Patel, L Jin Genes & Immunity 20 (1), 82-89, 2019 | 102 | 2019 |
| Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression A Nazmi, RH Field, EW Griffin, O Haugh, E Hennessy, D Cox, R Reis, ... Glia 67 (7), 1254-1276, 2019 | 94 | 2019 |
| Cyclic‐di‐GMP and cyclic‐di‐AMP activate the NLRP3 inflammasome AA Abdul‐Sater, I Tattoli, L Jin, A Grajkowski, A Levi, BH Koller, IC Allen, ... EMBO reports 14 (10), 900-906, 2013 | 93 | 2013 |
| MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3′–5′)-cyclic-di-guanosine-monophosphate in vivo SM Blaauboer, VD Gabrielle, L Jin The Journal of Immunology 192 (1), 492-502, 2014 | 89 | 2014 |
| The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo SM Blaauboer, S Mansouri, HR Tucker, HL Wang, VD Gabrielle, L Jin Elife 4, e06670, 2015 | 88 | 2015 |
| The common R71H-G230A-R293Q human TMEM173 is a null allele S Patel, SM Blaauboer, HR Tucker, S Mansouri, JS Ruiz-Moreno, ... The Journal of Immunology 198 (2), 776-787, 2017 | 66 | 2017 |
| Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation JJ Cho, Z Xu, U Parthasarathy, TT Drashansky, EY Helm, AN Zuniga, ... Nature communications 10 (1), 701, 2019 | 65 | 2019 |
| The age of cyclic dinucleotide vaccine adjuvants H Gogoi, S Mansouri, L Jin Vaccines 8 (3), 453, 2020 | 63 | 2020 |
| STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses IK Vila, H Chamma, A Steer, M Saccas, C Taffoni, E Turtoi, LS Reinert, ... Cell Metabolism 34 (1), 125-139. e8, 2022 | 60 | 2022 |
| STING/MPYS mediates host defense against listeria monocytogenes infection by regulating ly6chi monocyte migration L Jin, A Getahun, HM Knowles, J Mogan, LJ Akerlund, TA Packard, ... The Journal of Immunology 190 (6), 2835-2843, 2013 | 59 | 2013 |
| Cellular reactive oxygen species inhibit MPYS induction of IFNβ L Jin, LL Lenz, JC Cambier PLoS One 5 (12), e15142, 2010 | 56 | 2010 |
| Growing tumors induce a local STING dependent Type I IFN response in dendritic cells L Andzinski, J Spanier, N Kasnitz, A Kröger, L Jin, MM Brinkmann, ... International journal of cancer 139 (6), 1350-1357, 2016 | 55 | 2016 |
Katherine FitzgeraldProfessor of Medicine, University of Massachusetts Medical SchoolVerified email at umassmed.edu
