AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC V Hornung, A Ablasser, M Charrel-Dennis, F Bauernfeind, G Horvath, ... Nature 458 (7237), 514-518, 2009 | 2925 | 2009 |
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 V Hornung, M Guenthner-Biller, C Bourquin, A Ablasser, M Schlee, ... Nature medicine 11 (3), 263-270, 2005 | 1756 | 2005 |
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING A Ablasser, M Goldeck, T Cavlar, T Deimling, G Witte, I Röhl, KP Hopfner, ... Nature 498 (7454), 380-384, 2013 | 1612 | 2013 |
The cGAS–STING pathway as a therapeutic target in inflammatory diseases A Decout, JD Katz, S Venkatraman, A Ablasser Nature Reviews Immunology 21 (9), 548-569, 2021 | 1232 | 2021 |
RIG-I-dependent sensing of poly (dA: dT) through the induction of an RNA polymerase III–transcribed RNA intermediate A Ablasser, F Bauernfeind, G Hartmann, E Latz, KA Fitzgerald, V Hornung Nature immunology 10 (10), 1065-1072, 2009 | 1113 | 2009 |
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence S Glück, B Guey, MF Gulen, K Wolter, TW Kang, NA Schmacke, ... Nature cell biology 19 (9), 1061-1070, 2017 | 995 | 2017 |
Structural mechanism of cytosolic DNA sensing by cGAS F Civril, T Deimling, CC de Oliveira Mann, A Ablasser, M Moldt, G Witte, ... Nature 498 (7454), 332-337, 2013 | 830 | 2013 |
Targeting STING with covalent small-molecule inhibitors SM Haag, MF Gulen, L Reymond, A Gibelin, L Abrami, A Decout, ... Nature 559 (7713), 269-273, 2018 | 819 | 2018 |
cGAS in action: Expanding roles in immunity and inflammation A Ablasser, ZJ Chen Science 363 (6431), eaat8657, 2019 | 808 | 2019 |
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP A Ablasser, JL Schmid-Burgk, I Hemmerling, GL Horvath, T Schmidt, ... Nature 503 (7477), 530-534, 2013 | 678 | 2013 |
Inflammasomes: current understanding and open questions F Bauernfeind, A Ablasser, E Bartok, S Kim, J Schmid-Burgk, T Cavlar, ... Cellular and Molecular Life Sciences 68, 765-783, 2011 | 487 | 2011 |
Signalling strength determines proapoptotic functions of STING MF Gulen, U Koch, SM Haag, F Schuler, L Apetoh, A Villunger, F Radtke, ... Nature communications 8 (1), 427, 2017 | 424 | 2017 |
Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1 R Wassermann, MF Gulen, C Sala, SG Perin, Y Lou, J Rybniker, ... Cell host & microbe 17 (6), 799-810, 2015 | 412 | 2015 |
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19 JD Domizio, MF Gulen, F Saidoune, VV Thacker, A Yatim, K Sharma, ... Nature 603 (7899), 145-151, 2022 | 397 | 2022 |
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids V Hornung, R Hartmann, A Ablasser, KP Hopfner Nature Reviews Immunology 14 (8), 521-528, 2014 | 368 | 2014 |
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome S Kim, F Bauernfeind, A Ablasser, G Hartmann, KA Fitzgerald, E Latz, ... European journal of immunology 40 (6), 1545-1551, 2010 | 316 | 2010 |
cGAS–STING drives ageing-related inflammation and neurodegeneration MF Gulen, N Samson, A Keller, M Schwabenland, C Liu, S Glück, ... Nature 620 (7973), 374-380, 2023 | 296 | 2023 |
Regulation of cGAS-and RLR-mediated immunity to nucleic acids A Ablasser, S Hur Nature immunology 21 (1), 17-29, 2020 | 271 | 2020 |
TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner A Ablasser, I Hemmerling, JL Schmid-Burgk, R Behrendt, A Roers, ... The Journal of Immunology 192 (12), 5993-5997, 2014 | 256 | 2014 |
Species‐specific detection of the antiviral small‐molecule compound CMA by STING T Cavlar, T Deimling, A Ablasser, KP Hopfner, V Hornung The EMBO journal 32 (10), 1440-1450, 2013 | 222 | 2013 |