Andrea Ablasser
Andrea Ablasser
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
V Hornung, A Ablasser, M Charrel-Dennis, F Bauernfeind, G Horvath, ...
Nature 458 (7237), 514-518, 2009
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
V Hornung, M Guenthner-Biller, C Bourquin, A Ablasser, M Schlee, ...
Nature medicine 11 (3), 263-270, 2005
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
A Ablasser, M Goldeck, T Cavlar, T Deimling, G Witte, I Röhl, KP Hopfner, ...
Nature 498 (7454), 380-384, 2013
RIG-I-dependent sensing of poly (dA: dT) through the induction of an RNA polymerase III–transcribed RNA intermediate
A Ablasser, F Bauernfeind, G Hartmann, E Latz, KA Fitzgerald, V Hornung
Nature immunology 10 (10), 1065-1072, 2009
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
S Glück, B Guey, MF Gulen, K Wolter, TW Kang, NA Schmacke, ...
Nature cell biology 19 (9), 1061-1070, 2017
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman, A Ablasser
Nature Reviews Immunology 21 (9), 548-569, 2021
Structural mechanism of cytosolic DNA sensing by cGAS
F Civril, T Deimling, CC de Oliveira Mann, A Ablasser, M Moldt, G Witte, ...
Nature 498 (7454), 332-337, 2013
Targeting STING with covalent small-molecule inhibitors
SM Haag, MF Gulen, L Reymond, A Gibelin, L Abrami, A Decout, ...
Nature 559 (7713), 269-273, 2018
cGAS in action: Expanding roles in immunity and inflammation
A Ablasser, ZJ Chen
Science 363 (6431), eaat8657, 2019
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
A Ablasser, JL Schmid-Burgk, I Hemmerling, GL Horvath, T Schmidt, ...
Nature 503 (7477), 530-534, 2013
Inflammasomes: current understanding and open questions
F Bauernfeind, A Ablasser, E Bartok, S Kim, J Schmid-Burgk, T Cavlar, ...
Cellular and Molecular Life Sciences 68, 765-783, 2011
Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1
R Wassermann, MF Gulen, C Sala, SG Perin, Y Lou, J Rybniker, ...
Cell host & microbe 17 (6), 799-810, 2015
Signalling strength determines proapoptotic functions of STING
MF Gulen, U Koch, SM Haag, F Schuler, L Apetoh, A Villunger, F Radtke, ...
Nature communications 8 (1), 427, 2017
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
V Hornung, R Hartmann, A Ablasser, KP Hopfner
Nature Reviews Immunology 14 (8), 521-528, 2014
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
S Kim, F Bauernfeind, A Ablasser, G Hartmann, KA Fitzgerald, E Latz, ...
European journal of immunology 40 (6), 1545-1551, 2010
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
JD Domizio, MF Gulen, F Saidoune, VV Thacker, A Yatim, K Sharma, ...
Nature 603 (7899), 145-151, 2022
TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner
A Ablasser, I Hemmerling, JL Schmid-Burgk, R Behrendt, A Roers, ...
The Journal of Immunology 192 (12), 5993-5997, 2014
Regulation of cGAS-and RLR-mediated immunity to nucleic acids
A Ablasser, S Hur
Nature immunology 21 (1), 17-29, 2020
Species‐specific detection of the antiviral small‐molecule compound CMA by STING
T Cavlar, T Deimling, A Ablasser, KP Hopfner, V Hornung
The EMBO journal 32 (10), 1440-1450, 2013
Structural mechanism of cGAS inhibition by the nucleosome
GR Pathare, A Decout, S Glück, S Cavadini, K Makasheva, R Hovius, ...
Nature 587 (7835), 668-672, 2020
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