| The E3 ligase TRAF6 regulates Akt ubiquitination and activation WL Yang, J Wang, CH Chan, SW Lee, AD Campos, B Lamothe, L Hur, ... Science 325 (5944), 1134-1138, 2009 | 641 | 2009 |
| Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence HK Lin, Z Chen, G Wang, C Nardella, SW Lee, CH Chan, WL Yang, ... Nature 464 (7287), 374-379, 2010 | 473 | 2010 |
| The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis CH Chan, CF Li, WL Yang, Y Gao, SW Lee, Z Feng, HY Huang, KKC Tsai, ... Cell 149 (5), 1098-1111, 2012 | 419 | 2012 |
| Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression CH Chan, JK Morrow, CF Li, Y Gao, G Jin, A Moten, LJ Stagg, JE Ladbury, ... Cell 154 (3), 556-568, 2013 | 397 | 2013 |
| Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB HK Lin, G Wang, Z Chen, J Teruya-Feldstein, Y Liu, CH Chan, WL Yang, ... Nature cell biology 11 (4), 420-432, 2009 | 277 | 2009 |
| UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells JH Kim, A Sharma, SS Dhar, SH Lee, B Gu, CH Chan, HK Lin, MG Lee Cancer research 74 (6), 1705-1717, 2014 | 242 | 2014 |
| Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation F Wang, CH Chan, K Chen, X Guan, HK Lin, Q Tong Oncogene 31 (12), 1546-1557, 2012 | 241 | 2012 |
| Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis CH Chan, SW Lee, CF Li, J Wang, WL Yang, CY Wu, J Wu, KI Nakayama, ... Nature cell biology 12 (5), 457-467, 2010 | 236 | 2010 |
| KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling KW Wagner, H Alam, SS Dhar, U Giri, N Li, Y Wei, D Giri, T Cascone, ... The Journal of clinical investigation 123 (12), 5231-5246, 2013 | 187 | 2013 |
| Posttranslational regulation of Akt in human cancer CH Chan, U Jo, A Kohrman, AH Rezaeian, PC Chou, C Logothetis, ... Cell & bioscience 4, 1-9, 2014 | 145 | 2014 |
| Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1 J Wu, X Zhang, L Zhang, CY Wu, AH Rezaeian, CH Chan, JM Li, J Wang, ... Molecular cell 46 (3), 351-361, 2012 | 140 | 2012 |
| Regulation of Skp2 expression and activity and its role in cancer progression CH Chan, SW Lee, J Wang, HK Lin The Scientific World JOURNAL 10, 1001-1015, 2010 | 139 | 2010 |
| Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress SW Lee, CF Li, G Jin, Z Cai, F Han, CH Chan, WL Yang, BK Li, ... Molecular cell 57 (6), 1022-1033, 2015 | 128 | 2015 |
| Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis D Xu, CF Li, X Zhang, Z Gong, CH Chan, SW Lee, G Jin, AH Rezaeian, ... Nature communications 6 (1), 6641, 2015 | 114 | 2015 |
| JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis N Li, SS Dhar, TY Chen, PY Kan, Y Wei, JH Kim, CH Chan, HK Lin, ... Cancer research 76 (4), 831-843, 2016 | 110 | 2016 |
| Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response CY Wu, HY Kang, WL Yang, J Wu, YS Jeong, J Wang, CH Chan, SW Lee, ... Journal of Biological Chemistry 286 (35), 30806-30815, 2011 | 100 | 2011 |
| Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion HJ Lee, CF Li, D Ruan, J He, ED Montal, S Lorenz, GD Girnun, CH Chan Nature communications 10 (1), 2625, 2019 | 94 | 2019 |
| The DNA damage transducer RNF8 facilitates cancer chemoresistance and progression through twist activation HJ Lee, CF Li, D Ruan, S Powers, PA Thompson, MA Frohman, CH Chan Molecular cell 63 (6), 1021-1033, 2016 | 86 | 2016 |
| Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis G Wang, CH Chan, Y Gao, HK Lin Chinese journal of cancer 31 (4), 169, 2012 | 85 | 2012 |
| Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1 G Jin, SW Lee, X Zhang, Z Cai, Y Gao, PC Chou, AH Rezaeian, F Han, ... Molecular cell 58 (6), 989-1000, 2015 | 79 | 2015 |
