| MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis MJ Delano, PO Scumpia, JS Weinstein, D Coco, S Nagaraj, ... The Journal of experimental medicine 204 (6), 1463-1474, 2007 | 811 | 2007 |
| Effect of gender and sex hormones on immune responses following shock MK Angele, MG Schwacha, A Ayala, IH Chaudry Shock 14 (2), 81-90, 2000 | 629 | 2000 |
| PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis X Huang, F Venet, YL Wang, A Lepape, Z Yuan, Y Chen, R Swan, ... Proceedings of the National Academy of Sciences 106 (15), 6303-6308, 2009 | 543 | 2009 |
| The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients NS Ward, B Casserly, A Ayala Clinics in chest medicine 29 (4), 617-625, 2008 | 493 | 2008 |
| Leukocyte apoptosis and its significance in sepsis and shock DE Wesche, JL Lomas-Neira, M Perl, CS Chung, A Ayala Journal of leukocyte biology 78 (2), 325-337, 2005 | 488 | 2005 |
| Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males R Zellweger, MW Wichmann, A Ayala, S Stein, CM DeMaso, IH Chaudry Critical care medicine 25 (1), 106-110, 1997 | 444 | 1997 |
| Early kidney TNF-α expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion KK Donnahoo, X Meng, A Ayala, MP Cain, AH Harken, DR Meldrum American Journal of Physiology-Regulatory, Integrative and Comparative …, 1999 | 410 | 1999 |
| Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock EA Deitch, D Xu, L Franko, A Ayala, IH Chaudry Shock 1 (2), 141-145, 1994 | 394 | 1994 |
| Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients F Venet, CS Chung, H Kherouf, A Geeraert, C Malcus, F Poitevin, J Bohé, ... Intensive care medicine 35, 678-686, 2009 | 387 | 2009 |
| The complex pattern of cytokines in sepsis association between prostaglandins, cachectin, and interleukins W ERTEL, MH MORRISON, P WANG, ZF BA, A AYALA, IH CHAUDRY Annals of surgery 214 (2), 141-148, 1991 | 350 | 1991 |
| Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage A Ayala, P Wang, ZF Ba, MM Perrin, W Ertel, IH Chaudry American Journal of Physiology-Regulatory, Integrative and Comparative …, 1991 | 341 | 1991 |
| Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators A Ayala, CD Herdon, DL Lehman, CA Ayala, IH Chaudry | 340 | 1996 |
| Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients C Guignant, A Lepape, X Huang, H Kherouf, L Denis, F Poitevin, ... Critical care 15, 1-11, 2011 | 335 | 2011 |
| Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation MW Wichmann, R Zellweger, CM DeMaso, A Ayala, IH Chaudry Cytokine 8 (11), 853-863, 1996 | 299 | 1996 |
| Regulatory T cell populations in sepsis and trauma F Venet, CS Chung, G Monneret, X Huang, B Horner, M Garber, A Ayala Journal of Leucocyte Biology 83 (3), 523-535, 2008 | 294 | 2008 |
| The new normal: immunomodulatory agents against sepsis immune suppression NA Hutchins, J Unsinger, RS Hotchkiss, A Ayala Trends in molecular medicine 20 (4), 224-233, 2014 | 288 | 2014 |
| Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin A Ayala, MM Perrin, DR Meldrum, W Ertel, IH Chaudry Cytokine 2 (3), 170-174, 1990 | 267 | 1990 |
| Testosterone receptor blockade after hemorrhage in males: restoration of the depressed immune functions and improved survival following subsequent sepsis MK Angele, MW Wichmann, A Ayala, WG Cioffi, IH Chaudry Archives of Surgery 132 (11), 1207-1214, 1997 | 251 | 1997 |
| Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis MF Osuchowski, A Ayala, S Bahrami, M Bauer, M Boros, JM Cavaillon, ... Intensive care medicine experimental 6, 1-6, 2018 | 247 | 2018 |
| Mechanism of immunosuppression in males following trauma-hemorrhage: critical role of testosterone MW Wichmann, R Zellweger, CM DeMaso, A Ayala, IH Chaudry Archives of Surgery 131 (11), 1186-1192, 1996 | 246 | 1996 |
