| Membrane transporters in drug development Nature reviews Drug discovery 9 (3), 215-236, 2010 | 3483 | 2010 |
| A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity C Kimchi-Sarfaty, JM Oh, IW Kim, ZE Sauna, AM Calcagno, SV Ambudkar, ... Science 315 (5811), 525-528, 2007 | 3017 | 2007 |
| Biochemical, cellular, and pharmacological aspects of the multidrug transporter SV Ambudkar, S Dey, CA Hrycyna, M Ramachandra, I Pastan, ... Annual review of pharmacology and toxicology 39 (1), 361-398, 1999 | 2766 | 1999 |
| P-glycoprotein: from genomics to mechanism SV Ambudkar, C Kimchi-Sarfaty, ZE Sauna, MM Gottesman Oncogene 22 (47), 7468-7485, 2003 | 1384 | 2003 |
| Brca1 breast tumors contain distinct CD44+/CD24- and CD133+cells with cancer stem cell characteristics MH Wright, AM Calcagno, CD Salcido, MD Carlson, SV Ambudkar, ... Breast cancer research 10, 1-16, 2008 | 822 | 2008 |
| Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein ML Zeidel, SV Ambudkar, BL Smith, P Agre Biochemistry 31 (33), 7436-7440, 1992 | 717 | 1992 |
| P-glycoprotein and multidrug resistance MM Gottesman, I Pastan, SV Ambudkar Current opinion in genetics & development 6 (5), 610-617, 1996 | 699 | 1996 |
| HIV-1 Protease Inhibitors Are Substrates for the MDR1 Multidrug Transporter CGL Lee, MM Gottesman, CO Cardarelli, M Ramachandra, KT Jeang, ... Biochemistry 37 (11), 3594-3601, 1998 | 582 | 1998 |
| Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance JP Gillet, AM Calcagno, S Varma, M Marino, LJ Green, MI Vora, C Patel, ... Proceedings of the National Academy of Sciences 108 (46), 18708-18713, 2011 | 554 | 2011 |
| Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity J Tam, VK Vemuri, J Liu, S Bátkai, B Mukhopadhyay, G Godlewski, ... The Journal of clinical investigation 120 (8), 2953-2966, 2010 | 523 | 2010 |
| Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. SV Ambudkar, IH Lelong, J Zhang, CO Cardarelli, MM Gottesman, ... Proceedings of the National Academy of Sciences 89 (18), 8472-8476, 1992 | 514 | 1992 |
| Overview: ABC transporters and human disease MM Gottesman, SV Ambudkar Journal of bioenergetics and biomembranes 33, 453-458, 2001 | 509 | 2001 |
| Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein S Dey, M Ramachandra, I Pastan, MM Gottesman, SV Ambudkar Proceedings of the National Academy of Sciences 94 (20), 10594-10599, 1997 | 468 | 1997 |
| Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2 C Dai, AK Tiwari, CP Wu, X Su, SR Wang, D Liu, CR Ashby Jr, Y Huang, ... Cancer research 68 (19), 7905-7914, 2008 | 429 | 2008 |
| Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells S Anuchapreeda, P Leechanachai, MM Smith, SV Ambudkar, P Limtrakul Biochemical pharmacology 64 (4), 573-582, 2002 | 393 | 2002 |
| Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters Y Mi, Y Liang, H Huang, H Zhao, CP Wu, F Wang, L Tao, C Zhang, CL Dai, ... Cancer research 70 (20), 7981-7991, 2010 | 379 | 2010 |
| Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state M Ramachandra, SV Ambudkar, D Chen, CA Hrycyna, S Dey, ... Biochemistry 37 (14), 5010-5019, 1998 | 356 | 1998 |
| Silent (synonymous) SNPs: should we care about them? R Hunt, ZE Sauna, SV Ambudkar, MM Gottesman, C Kimchi-Sarfaty Single nucleotide polymorphisms: methods and protocols, 23-39, 2009 | 351 | 2009 |
| Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2–mediated drug resistance Z Shi, XX Peng, IW Kim, S Shukla, QS Si, RW Robey, SE Bates, T Shen, ... Cancer research 67 (22), 11012-11020, 2007 | 337 | 2007 |
| Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman Cancer research 67 (20), 9609-9612, 2007 | 333 | 2007 |
Zuben SaunaPrincipal Investigator, Food and Drug AdministrationVerified email at fda.hhs.gov
