Dhiren Thakker
Dhiren Thakker
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Tumorigenicity of the optical enantiomers of the diastereomeric benzo [a] pyrene 7, 8-diol-9, 10-epoxides in newborn mice: exceptional activity of (+)-7beta, 8alpha-dihydroxy …
MK Buening, PG Wislocki, W Levin, H Yagi, DR Thakker, H Akagi, ...
Proceedings of the National Academy of Sciences 75 (11), 5358-5361, 1978
Polycyclic aromatic hydrocarbons: metabolic activation to ultimate carcinogens
DR Thakker, H Yagi, W Levin, AW Wood, AH Conney, DM Jerina
Bioactivation of foreign compounds, 177-242, 1985
Metabolism of benzo [a] pyrene: conversion of (+/-)-trans-7, 8-dihydroxy-7, 8-dihydrobenzo [a] pyrene to highly mutagenic 7, 8-diol-9, 10-epoxides.
DR Thakker, H Yagi, AY Lu, W Levin, AH Conney
Proceedings of the National Academy of Sciences 73 (10), 3381-3385, 1976
Metabolism of benzo [a] pyrene VI. Stereoselective metabolism of benzo [a] pyrene and benzo [a] pyrene 7, 8-dihydrodiol to diol epoxides
DR Thakker, H Yagi, H Akagi, M Koreeda, AYH Lu, W Levin, AW Wood, ...
Chemico-biological interactions 16 (3), 281-300, 1977
Enhancing paracellular permeability by modulating epithelial tight junctions
PD Ward, TK Tippin, DR Thakker
Pharmaceutical science & technology today 3 (10), 346-358, 2000
Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium
LSL Gan, DR Thakker
Advanced Drug Delivery Reviews 23 (1-3), 77-98, 1997
Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo [a] pyrene 7, 8-diol-9, 10-epoxides
AW Wood, RL Chang, W Levin, H Yagi, DR Thakker, DM Jerina, ...
Biochemical and Biophysical Research Communications 77 (4), 1389-1396, 1977
Synthesis and reactions of the highly mutagenic 7, 8-diol 9, 10-epoxides of the carcinogen benzo [a] pyrene
H Yagi, DR Thakker, O Hernandez, M Koreeda, DM Jerina
Journal of the American Chemical Society 99 (5), 1604-1611, 1977
Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporine A transport
PF Augustijns, TP Bradshaw, LSL Gan, RW Hendren, DR Thakker
Biochemical and biophysical research communications 197 (2), 360-365, 1993
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.
LS Gan, MA Moseley, B Khosla, PF Augustijns, TP Bradshaw, ...
Drug Metabolism and Disposition 24 (3), 344-349, 1996
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium
MD Troutman, DR Thakker
Pharmaceutical research 20, 1210-1224, 2003
Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes
M Nordqvist, DR Thakker, KP Vyas, H Yagi, W Levin, DE Ryan, ...
Molecular pharmacology 19 (1), 168-178, 1981
Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 …
MD Troutman, DR Thakker
Pharmaceutical research 20, 1200-1209, 2003
Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens
W Levin, A Wood, R Chang, D Ryan, P Thomas, H Yagi, D Thakker, ...
Drug metabolism reviews 13 (4), 555-580, 1982
Mechanisms underlying saturable intestinal absorption of metformin
WR Proctor, DL Bourdet, DR Thakker
Drug Metabolism and Disposition 36 (8), 1650-1658, 2008
Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells
MD Troutman, DR Thakker
Pharmaceutical research 20, 1192-1199, 2003
Prodrugs of anticancer agents
AK Sinhababu, DR Thakker
Advanced drug delivery reviews 19 (2), 241-273, 1996
In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3
SB Yanni, PP Annaert, P Augustijns, JG Ibrahim, DK Benjamin, ...
Drug Metabolism and Disposition 38 (1), 25-31, 2010
Evidence That Benzo(a)anthracene 3,4-Diol-1,2-Epoxide Is an Ultimate Carcinogen on Mouse Skin
W Levin, DR Thakker, AW Wood, RL Chang, RE Lehr, DM Jerina, ...
Cancer research 38 (6), 1705-1710, 1978
Tumorigenicity of Optical Isomers of the Diastereomeric Bay-Region 3,4-Diol-1,2-epoxides of Benzo(c)phenanthrene in Murine Tumor Models
W Levin, RL Chang, AW Wood, DR Thakker, H Yagi, DM Jerina, ...
Cancer research 46 (5), 2257-2261, 1986
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