József Tőzsér
József Tőzsér
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen
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Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency
RB Kapust, J Tözsér, JD Fox, DE Anderson, S Cherry, TD Copeland, ...
Protein engineering 14 (12), 993-1000, 2001
The P1′ specificity of tobacco etch virus protease
RB Kapust, J Tözsér, TD Copeland, DS Waugh
Biochemical and biophysical research communications 294 (5), 949-955, 2002
Research applications of proteolytic enzymes in molecular biology
JA Mótyán, F Tóth, J Tőzsér
Biomolecules 3 (4), 923-942, 2013
Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins
J Tözsér, I Bláha, TD Copeland, EM Wondrak, S Oroszlan
FEBS letters 281 (1-2), 77-80, 1991
Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease
T Sperka, J Pitlik, P Bagossi, J Tözsér
Bioorganic & medicinal chemistry letters 15 (12), 3086-3090, 2005
Efficient site-specific processing of fusion proteins by tobacco vein mottling virus protease in vivo and in vitro
S Nallamsetty, RB Kapust, J Tözsér, S Cherry, JE Tropea, TD Copeland, ...
Protein expression and purification 38 (1), 108-115, 2004
Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages
MM Budai, A Varga, S Milesz, J Tőzsér, S Benkő
Molecular immunology 56 (4), 471-479, 2013
Kinetic and modeling studies of S3-S3'subsites of HIV proteinases
J Tozser, IT Weber, A Gustchina, I Blaha, TD Copeland, JM Louis, ...
Biochemistry 31 (20), 4793-4800, 1992
Quantitative analysis of proteins in the tear fluid of patients with diabetic retinopathy
É Csősz, P Boross, A Csutak, A Berta, F Tóth, S Póliska, Z Török, J Tőzsér
Journal of proteomics 75 (7), 2196-2204, 2012
Folded monomer of HIV-1 protease
R Ishima, R Ghirlando, J Tözsér, AM Gronenborn, DA Torchia, JM Louis
Journal of Biological Chemistry 276 (52), 49110-49116, 2001
Natural compounds as regulators of NLRP3 inflammasome-mediated IL-1β production
J Tőzsér, S Benkő
Mediators of Inflammation 2016, 2016
Atomic resolution crystal structures of HIV‐1 protease and mutants V82A and I84V with saquinavir
Y Tie, AY Kovalevsky, P Boross, YF Wang, AK Ghosh, J Tozser, ...
Proteins: Structure, Function, and Bioinformatics 67 (1), 232-242, 2007
Changes in the chemical barrier composition of tears in Alzheimer’s disease reveal potential tear diagnostic biomarkers
G Kalló, M Emri, Z Varga, B Ujhelyi, J Tőzsér, A Csutak, É Csősz
PLoS One 11 (6), e0158000, 2016
Effect of sequence polymorphism and drug resistance on two HIV‐1 Gag processing sites
A Fehér, IT Weber, P Bagossi, P Boross, B Mahalingam, JM Louis, ...
European journal of biochemistry 269 (16), 4114-4120, 2002
HIV-I protease: Maturation, enzyme specificity, and drug resistance
JM Louis, IT Webert, J Tözsér, GM Clore, AM Gronenborn
Advances in pharmacology 49, 111-146, 2000
Substitution of proline with pipecolic acid at the scissile bond converts a peptide substrate of HIV proteinase into a selective inhibitor
TD Copeland, EM Wondrak, J Tozser, MM Roberts, S Oroszlan
Biochemical and biophysical research communications 169 (1), 310-314, 1990
Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Ĺ resolution crystal structures of HIV‐1 protease mutants with substrate analogs
Y Tie, PI Boross, YF Wang, L Gaddis, F Liu, X Chen, J Tozser, ...
The FEBS journal 272 (20), 5265-5277, 2005
Studies on the role of the S4 substrate binding site of HIV proteinases
J Tözsér, A Gustchina, IT Weber, I Blaha, EM Wondrak, S Oroszlan
FEBS letters 279 (2), 356-360, 1991
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S
F Liu, PI Boross, YF Wang, J Tozser, JM Louis, RW Harrison, IT Weber
Journal of molecular biology 354 (4), 789-800, 2005
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir‐binding site
B Mahalingam, YF Wang, PI Boross, J Tozser, JM Louis, RW Harrison, ...
European journal of biochemistry 271 (8), 1516-1524, 2004
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