Helen Zgurskaya
Helen Zgurskaya
Professor of Chemistry and Biochemistry
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Cited by
Cited by
Tackling antibiotic resistance
K Bush, P Courvalin, G Dantas, J Davies, B Eisenstein, P Huovinen, ...
Nature Reviews Microbiology 9 (12), 894-896, 2011
Multidrug resistance mechanisms: drug efflux across two membranes
HI Zgurskaya, H Nikaido
Molecular microbiology 37 (2), 219-225, 2000
Permeability barrier of Gram-negative cell envelopes and approaches to bypass it
HI Zgurskaya, CA López, S Gnanakaran
ACS infectious diseases 1 (11), 512-522, 2015
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
EW Yu, G McDermott, HI Zgurskaya, H Nikaido, DE Koshland Jr
Science 300 (5621), 976-980, 2003
Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
HI Zgurskaya, H Nikaido
Proceedings of the National Academy of Sciences 96 (13), 7190-7195, 1999
Conformational flexibility in the multidrug efflux system protein AcrA
J Mikolosko, K Bobyk, HI Zgurskaya, P Ghosh
Structure 14 (3), 577-587, 2006
AcrA, AcrB, and TolC of Escherichia coli form a stable intermembrane multidrug efflux complex
EB Tikhonova, HI Zgurskaya
Journal of Biological Chemistry 279 (31), 32116-32124, 2004
AcrAB and related multidrug efflux pumps of Escherichia coli
H Nikaido, HI Zgurskaya
Journal of molecular microbiology and biotechnology 3 (2), 215-218, 2001
AcrA is a highly asymmetric protein capable of spanning the periplasm
HI Zgurskaya, H Nikaido
Journal of molecular biology 285 (1), 409-420, 1999
Mechanism and function of the outer membrane channel TolC in multidrug resistance and physiology of enterobacteria
HI Zgurskaya, G Krishnamoorthy, A Ntreh, S Lu
Frontiers in microbiology 2, 189, 2011
Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria
EB Tikhonova, Q Wang, HI Zgurskaya
Journal of bacteriology 184 (23), 6499-6507, 2002
Waltzing transporters and'the dance macabre'between humans and bacteria
O Lomovskaya, HI Zgurskaya, M Totrov, WJ Watkins
Nature reviews Drug discovery 6 (1), 56-65, 2007
Cross-Linked Complex between Oligomeric Periplasmic Lipoprotein AcrA and the Inner-Membrane-Associated Multidrug Efflux Pump AcrB from Escherichia coli
HI Zgurskaya, H Nikaido
Journal of bacteriology 182 (15), 4264-4267, 2000
Synergy between active efflux and outer membrane diffusion defines rules of antibiotic permeation into Gram-negative bacteria
G Krishnamoorthy, IV Leus, JW Weeks, D Wolloscheck, VV Rybenkov, ...
MBio 8 (5), 10.1128/mbio. 01172-17, 2017
Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC
EB Tikhonova, Y Yamada, HI Zgurskaya
Chemistry & biology 18 (4), 454-463, 2011
Rathayibacter gen. nov., Including the Species Rathayibacter rathayi comb. nov., Rathayibacter tritici comb. nov., Rathayibacter iranicus comb. nov., and Six …
HI Zgurskaya, LI Evtushenko, VN Akimov, LV Kalakoutskii
International Journal of Systematic and Evolutionary Microbiology 43 (1 …, 1993
Breaking the permeability barrier of Escherichia coli by controlled hyperporination of the outer membrane
G Krishnamoorthy, D Wolloscheck, JW Weeks, C Croft, VV Rybenkov, ...
Antimicrobial agents and chemotherapy 60 (12), 7372-7381, 2016
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB
EB Tikhonova, VK Devroy, SY Lau, HI Zgurskaya
Molecular microbiology 63 (3), 895-910, 2007
Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump
N Abdali, JM Parks, KM Haynes, JL Chaney, AT Green, D Wolloscheck, ...
ACS infectious diseases 3 (1), 89-98, 2017
Substrate specificities and efflux efficiencies of RND efflux pumps of Acinetobacter baumannii
IV Leus, JW Weeks, V Bonifay, L Smith, S Richardson, HI Zgurskaya
Journal of bacteriology 200 (13), 10.1128/jb. 00049-18, 2018
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