|Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program|
AL Shaffer, KI Lin, TC Kuo, X Yu, EM Hurt, A Rosenwald, JM Giltnane, ...
Immunity 17 (1), 51-62, 2002
|Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells|
KI Lin, C Angelin-Duclos, TC Kuo, K Calame
Molecular and cellular biology 22 (13), 4771-4780, 2002
|Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR|
SM Ranuncolo, JM Polo, J Dierov, M Singer, T Kuo, J Greally, R Green, ...
Nature immunology 8 (7), 705-714, 2007
|B cell exchange across the blood-brain barrier in multiple sclerosis|
HC von Büdingen, TC Kuo, M Sirota, CJ van Belle, L Apeltsin, J Glanville, ...
The Journal of clinical investigation 122 (12), 4533-4543, 2012
|Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation|
J Glanville, TC Kuo, HC von Büdingen, L Guey, J Berka, PD Sundar, ...
Proceedings of the National Academy of Sciences 108 (50), 20066-20071, 2011
|Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis|
A Palanichamy, L Apeltsin, TC Kuo, M Sirota, S Wang, SJ Pitts, ...
Science translational medicine 6 (248), 248ra106-248ra106, 2014
|B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites|
TC Kuo, KL Calame
The Journal of Immunology 173 (9), 5556-5563, 2004
|Repression of BCL-6 is required for the formation of human memory B cells in vitro|
TC Kuo, AL Shaffer, J Haddad Jr, YS Choi, LM Staudt, K Calame
The Journal of experimental medicine 204 (4), 819-830, 2007
|Mechanisms controlling expression of the RAG locus during lymphocyte development|
TC Kuo, MS Schlissel
Current opinion in immunology 21 (2), 173-178, 2009
|ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile|
SE Kauder, TC Kuo, O Harrabi, A Chen, E Sangalang, L Doyle, SS Rocha, ...
PloS one 13 (8), e0201832, 2018
|Preclinical evaluation of allogeneic CAR T cells targeting BCMA for the treatment of multiple myeloma|
C Sommer, B Boldajipour, TC Kuo, T Bentley, J Sutton, A Chen, T Geng, ...
Molecular therapy 27 (6), 1126-1138, 2019
|The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content|
J Benichou, J Glanville, ETL Prak, R Azran, TC Kuo, J Pons, C Desmarais, ...
The Journal of Immunology 190 (11), 5567-5577, 2013
|Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation|
MAJ Morgan, E Magnusdottir, TC Kuo, C Tunyaplin, J Harper, SJ Arnold, ...
Molecular and cellular biology 29 (21), 5813-5827, 2009
|Mutation of csk, encoding the C-terminal Src kinase, reduces Pseudomonas aeruginosa internalization by mammalian cells and enhances bacterial cytotoxicity|
DJ Evans, TC Kuo, M Kwong, R Van, SMJ Fleiszig
Microbial pathogenesis 33 (3), 135-143, 2002
|Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα|
J Sim, JT Sockolosky, E Sangalang, S Izquierdo, D Pedersen, ...
MAbs 11 (6), 1036-1052, 2019
|Constructs having a SIRP-α domain or variant thereof|
J Pons, L Deming, C Goodman, BJ Sim, SE Kauder, H Wan, TCC Kuo
US Patent 10,259,859, 2019
|Preclinical efficacy and safety comparison of CD3 bispecific and ADC modalities targeting BCMA for the treatment of multiple myeloma|
SH Panowski, TC Kuo, Y Zhang, A Chen, T Geng, L Aschenbrenner, ...
Molecular cancer therapeutics 18 (11), 2008-2020, 2019
|Pseudomonas aeruginosa strains with lipopolysaccharide defects exhibit reduced intracellular viability after invasion of corneal epithelial cells|
D Evans, T Kuo, M Kwong, R Van, S Fleiszig
Experimental eye research 75 (6), 635-643, 2002
|Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity|
TC Kuo, A Chen, O Harrabi, JT Sockolosky, A Zhang, E Sangalang, ...
Journal of hematology & oncology 13 (1), 1-19, 2020
|Chimeric antigen receptors targeting B-cell maturation antigen|
TCC Kuo, BA Boldajipour, JFC Riggers, P Duchateau, R Galetto, ...
US Patent 10,294,304, 2019