| Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity K Xu, N Yin, M Peng, EG Stamatiades, A Shyu, P Li, X Zhang, MH Do, ... Science 371 (6527), 405-410, 2021 | 206 | 2021 |
| Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells S Li, M Liu, MH Do, C Chou, EG Stamatiades, BG Nixon, W Shi, X Zhang, ... Nature 587 (7832), 121-125, 2020 | 172 | 2020 |
| The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance F Han, CF Li, Z Cai, X Zhang, G Jin, WN Zhang, C Xu, CY Wang, J Morrow, ... Nature communications 9 (1), 4728, 2018 | 144 | 2018 |
| Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1 J Wu*, X Zhang*, L Zhang, CY Wu, AH Rezaelan, CH Chan, JM Li, ... Molecular cell, 2012 | 140 | 2012 |
| Phosphorylation of PDHA by AMPK drives TCA cycle to promote cancer metastasis Z Cai, CF Li, F Han, C Liu, A Zhang, CC Hsu, D Peng, X Zhang, G Jin, ... Molecular cell 80 (2), 263-278. e7, 2020 | 134 | 2020 |
| Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis D Xu, CF Li, X Zhang, Z Gong, CH Chan, SW Lee, G Jin, AH Rezaeian, ... Nature communications 6 (1), 6641, 2015 | 116 | 2015 |
| Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells G Jin, C Xu, X Zhang, J Long, AH Rezaeian, C Liu, ME Furth, S Kridel, ... Nature immunology 19 (1), 29-40, 2018 | 113 | 2018 |
| Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development WL Yang, X Zhang, HK Lin Oncogene 29 (32), 4493-4503, 2010 | 113 | 2010 |
| A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis AH Rezaeian, CF Li, CY Wu, X Zhang, J Delacerda, MJ You, F Han, Z Cai, ... Nature cell biology 19 (1), 38-51, 2017 | 102 | 2017 |
| Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response CY Wu, HY Kang, WL Yang, J Wu, YS Jeong, J Wang, CH Chan, SW Lee, ... Journal of Biological Chemistry 286 (35), 30806-30815, 2011 | 100 | 2011 |
| Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1 G Jin, SW Lee, X Zhang, Z Cai, Y Gao, PC Chou, AH Rezaeian, F Han, ... Molecular cell 58 (6), 989-1000, 2015 | 79 | 2015 |
| TRAF6 restricts p53 mitochondrial translocation, apoptosis, and tumor suppression X Zhang, CF Li, L Zhang, CY Wu, L Han, G Jin, AH Rezaeian, F Han, ... Molecular cell 64 (4), 803-814, 2016 | 75 | 2016 |
| The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal J Wang, F Han, J Wu, SW Lee, CH Chan, CY Wu, WL Yang, Y Gao, ... Blood, The Journal of the American Society of Hematology 118 (20), 5429-5438, 2011 | 64 | 2011 |
| Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses K Xu, N Yin, M Peng, EG Stamatiades, S Chhangawala, A Shyu, P Li, ... Immunity 54 (5), 976-987. e7, 2021 | 60 | 2021 |
| Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies ER Kansler, S Dadi, C Krishna, BG Nixon, EG Stamatiades, M Liu, F Kuo, ... Nature immunology 23 (6), 904-915, 2022 | 47 | 2022 |
| H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis X Zhang, B Li, AH Rezaeian, X Xu, PC Chou, G Jin, F Han, BS Pan, ... Nature communications 8 (1), 14799, 2017 | 46 | 2017 |
| Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK CC Hsu, X Zhang, G Wang, W Zhang, Z Cai, BS Pan, H Gu, C Xu, G Jin, ... Molecular cell 81 (18), 3803-3819. e7, 2021 | 42 | 2021 |
| Programme of self-reactive innate-like T cell-mediated cancer immunity C Chou*, X Zhang*, C Krishna, BG Nixon, S Dadi, KJ Capistrano, ... Nature 605 (7908), 139-145, 2022 | 41 | 2022 |
| Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex J Wu, SW Lee, X Zhang, F Han, SY Kwan, X Yuan, WL Yang, YS Jeong, ... Oncogene 32 (1), 78-85, 2013 | 40 | 2013 |
| Control of tumor-associated macrophage responses by nutrient acquisition and metabolism X Zhang, L Ji, MO Li Immunity 56 (1), 14-31, 2023 | 37 | 2023 |
Hui-Kuan LinDuke University School of MedicineVerified email at duke.edu
