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George Lountos
George Lountos
Basic Science Program, Frederick National Laboratory for Cancer Research
Verified email at mail.nih.gov
Title
Cited by
Cited by
Year
Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity
D Needle, GT Lountos, DS Waugh
Acta Crystallographica Section D: Biological Crystallography 71 (5), 1102-1111, 2015
1192015
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1 …
AG Jobson, GT Lountos, PL Lorenzi, J Llamas, J Connelly, D Cerna, ...
Journal of Pharmacology and Experimental Therapeutics 331 (3), 816-826, 2009
1122009
The Crystal Structure of NAD(P)H Oxidase from Lactobacillus sanfranciscensis:  Insights into the Conversion of O2 into Two Water Molecules by the Flavoenzyme,
GT Lountos, R Jiang, WB Wellborn, TL Thaler, AS Bommarius, AM Orville
Biochemistry 45 (32), 9648-9659, 2006
1112006
Role of Glu312 in Binding and Positioning of the Substrate for the Hydride Transfer Reaction in Choline Oxidase,
O Quaye, GT Lountos, Fan, AM Orville, G Gadda
Biochemistry 47 (1), 243-256, 2008
1042008
Crystallographic, Spectroscopic, and Computational Analysis of a Flavin C4a−Oxygen Adduct in Choline Oxidase,
AM Orville, GT Lountos, S Finnegan, G Gadda, R Prabhakar
Biochemistry 48 (4), 720-728, 2009
712009
Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion
GT Lountos, BP Austin, S Nallamsetty, DS Waugh
Protein Science 18 (2), 467-474, 2009
572009
Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia pestis Outer Protein H (YopH …
M Bahta, GT Lountos, B Dyas, SE Kim, RG Ulrich, DS Waugh, TR Burke Jr
Journal of medicinal chemistry 54 (8), 2933-2943, 2011
522011
Engineering of glycerol dehydrogenase for improved activity towards 1, 3-butanediol
H Zhang, GT Lountos, CB Ching, R Jiang
Applied microbiology and biotechnology 88, 117-124, 2010
382010
Insights into the allosteric inhibition of the SUMO E2 enzyme Ubc9
WM Hewitt, GT Lountos, K Zlotkowski, SD Dahlhauser, LB Saunders, ...
Angewandte Chemie 128 (19), 5797-5801, 2016
332016
Structure of B-DNA with Cations Tethered in the Major Groove,
T Moulaei, T Maehigashi, GT Lountos, S Komeda, D Watkins, MP Stone, ...
Biochemistry 44 (20), 7458-7468, 2005
332005
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor
GT Lountos, JE Tropea, D Zhang, AG Jobson, Y Pommier, RH Shoemaker, ...
Protein science 18 (1), 92-100, 2009
302009
Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic …
GT Lountos, XZ Zhao, E Kiselev, JE Tropea, D Needle, Y Pommier, ...
Nucleic Acids Research 47 (19), 10134-10150, 2019
282019
Overproduction, purification and structure determination of human dual-specificity phosphatase 14
GT Lountos, JE Tropea, S Cherry, DS Waugh
Acta Crystallographica Section D: Biological Crystallography 65 (10), 1013-1020, 2009
242009
Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy
GT Lountos, AG Jobson, JE Tropea, CR Self, G Zhang, Y Pommier, ...
Journal of structural biology 176 (3), 292-301, 2011
232011
A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH
F Liu, RM Hakami, B Dyas, M Bahta, GT Lountos, DS Waugh, RG Ulrich, ...
Bioorganic & medicinal chemistry letters 20 (9), 2813-2816, 2010
232010
Crystal Structures and Functional Studies of T4moD, the Toluene 4-Monooxygenase Catalytic Effector Protein,
GT Lountos, KH Mitchell, JM Studts, BG Fox, AM Orville
Biochemistry 44 (19), 7131-7142, 2005
232005
Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery
I Botos, GT Lountos, W Wu, S Cherry, R Ghirlando, AM Kudzhaev, ...
Current Research in Structural Biology 1, 13-20, 2019
212019
Phosphotyrosine substrate sequence motifs for dual specificity phosphatases
BM Zhao, SL Keasey, JE Tropea, GT Lountos, BK Dyas, S Cherry, ...
Plos one 10 (8), e0134984, 2015
202015
Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution
GT Lountos, JE Tropea, DS Waugh
Acta Crystallographica Section D: Biological Crystallography 67 (5), 471-479, 2011
202011
Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites
XZ Zhao, E Kiselev, GT Lountos, W Wang, JE Tropea, D Needle, ...
Chemical Science 12 (11), 3876-3884, 2021
192021
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